Evidence map›Paper›PMID 36948765›Full record

ArticleKidney international2023

A transitional B-cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection.

Sumoyee Basu, Anthony Dorling, Anita S Chong

Open access · greenAbstract readComment
In one paragraph

Article in Kidney international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Sumoyee BasuDepartment of Inflammation Biology, Centre for Nephrology, Urology and Transplantation, School of Immunology and Microbial Sciences, King's College London, London, UK.
Anthony DorlingDepartment of Inflammation Biology, Centre for Nephrology, Urology and Transplantation, School of Immunology and Microbial Sciences, King's College London, London, UK. Electronic address: anthony.dorling@kcl.ac.uk.
Anita S ChongDepartment of Surgery, The University of Chicago, Chicago, Illinois, USA.
King's College London · GBUniversity of Chicago · US

Funding

T cell mechanisms that distinguish robust tolerance from metastable allograft acceptance and failed tolerance (Project 2)P01AI097113 · NIAID · UNIVERSITY OF CHICAGO · PI Maria-Luisa Alegre, Anita S Chong · 2012 to 2026
$23.8M
Intrarenal B cells in acute kidney allograft rejectionR01AI148705 · NIAID · UNIVERSITY OF CHICAGO · PI CHONG, ANITA S, CLARK, MARCUS RAMSAY · 2020 to 2024
$4.0M
Deconstructing B cell transplantation toleranceR01AI142747 · NIAID · UNIVERSITY OF CHICAGO · PI CHONG, ANITA S · 2019 to 2022
$2.2M
Medical Research Council MR/T006560/1Medical Research Council MR/T025573/1NIAID NIH HHS P01 AI097113NIAID NIH HHS R01 AI142747NIAID NIH HHS R01 AI148705
6 · The paper itself

Abstract

Borderline allograft rejection can promote acute rejection and graft loss in some, but not all, patients. In this issue, Cherukuri et al. use a novel test based on peripheral blood transitional T1 B cells producing interleukin-10 and tumor necrosis factor-α, which identifies patients at high risk for poor outcomes. The potential mechanisms by which transitional T1 B cells might modulate alloreactivity need exploration, but following appropriate validation, this biomarker could risk stratify patients in need of early intervention.

Indexed as

Kidney TransplantationBiomarkersCytokinesGraft RejectionHumansPrecursor Cells, B-LymphoidBiomarkersCytokines

Identifiers

PMID36948765
PMCPMC10755754
OpenAlexW4327964448

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.