Evidence map›Paper›PMID 36948705›Full record

ArticleMethods in enzymology2023

Chemical and structural approaches to investigate PTEN function and regulation.

Thibault Viennet, Santiago Rodriguez Ospina, Yunqi Lu, Anna Cui, Haribabu Arthanari, Daniel R Dempsey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in enzymology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Exercise: a non-drug strategy of NK cell activation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Review
  3. Amoebae: beyond pathogens- exploring their benefits and future potential.Frontiers in cellular and infection microbiology · 2024
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Thibault ViennetDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.
Santiago Rodriguez OspinaDepartment of Dermatology, Boston University School of Medicine, Boston, MA, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.
Yunqi LuDepartment of Dermatology, Boston University School of Medicine, Boston, MA, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.
Anna CuiDepartment of Dermatology, Boston University School of Medicine, Boston, MA, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.
Haribabu ArthanariDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.
Daniel R DempseyDepartment of Dermatology, Boston University School of Medicine, Boston, MA, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States. Electronic address: ddempsey@bu.edu.
Boston University · USDana-Farber Cancer Institute · US

Funding

Molecular Mechanisms of PTEN and USP7 RegulationR00GM130961 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DEMPSEY, DANIEL R. · 2022 to 2024
$747k
NIGMS NIH HHS R00 GM130961
6 · The paper itself

Abstract

Phosphatase and tensin homolog is a lipid phosphatase that serves as the major negative regulator of the PI3K/AKT pathway. It catalyzes the 3'-specific dephosphorylation of phosphatidylinositol (3,4,5)-trisphosphate (PIP

Indexed as

Phosphatidylinositol 3-KinasesPTEN PhosphohydrolaseAmino AcidsLipidsPhosphorylationAmino AcidsLipidsPhosphatidylinositol 3-KinasesPTEN PhosphohydrolaseBiomolecular NMRC-terminal tailExpressed protein ligationPhosphorylationProtein X-ray crystallographyPTEN

Identifiers

PMID36948705
PMCPMC10037535
OpenAlexW4312429379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.