Evidence map›Paper›PMID 36948184›Full record

ArticleJournal of the American Chemical Society2023

MicroED Structure of a Protoglobin Reactive Carbene Intermediate.

Emma Danelius, Nicholas J Porter, Johan Unge, Frances H Arnold, Tamir Gonen

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Membrane protein structure and dynamics probed by MicroED.Biochemical Society transactions · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Unraveling atomic complexity from frozen samples.Structural dynamics (Melville, N.Y.) · 2025
    Article
  6. Article
  7. Article
  8. Biocatalytic Synthesis of α-Amino Esters via Nitrene C-H Insertion.Journal of the American Chemical Society · 2024
    Article
  9. AlphaFold two years on: Validation and impact.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Reaching the potential of electron diffraction.Cell reports. Physical science · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Electron counting with direct electron detectors in MicroED.Structure (London, England : 1993) · 2023
    Article
  15. Review
  16. MicroED in drug discovery.Current opinion in structural biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Emma DaneliusDepartment of Biological Chemistry, University of California, Los Angeles, 615 Charles E. Young Drive South, Los Angeles, California 90095, United States.ORCID 0000-0002-7322-9661
Nicholas J PorterDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, California 91125, United States.ORCID 0000-0002-9803-5310
Johan UngeDepartment of Biological Chemistry, University of California, Los Angeles, 615 Charles E. Young Drive South, Los Angeles, California 90095, United States.
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, California 91125, United States.ORCID 0000-0002-4027-364X
Tamir GonenDepartment of Biological Chemistry, University of California, Los Angeles, 615 Charles E. Young Drive South, Los Angeles, California 90095, United States.ORCID 0000-0002-9254-4069
California Institute of Technology · USHoward Hughes Medical Institute · USUniversity of California, Los Angeles · US

Funding

TRD4: Design and Engineering of MicroED hardware for nanocrystallization and time resolved studiesP41GM136508 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GONEN, TAMIR · 2020 to 2024
$7.6M
Howard Hughes Medical InstituteNIGMS NIH HHS P41 GM136508
6 · The paper itself

Abstract

Microcrystal electron diffraction (MicroED) is an emerging technique that has shown great potential for describing new chemical and biological molecular structures. Several important structures of small molecules, natural products, and peptides have been determined using

Indexed as

ElectronsProteinsMethanePeptidescarbeneMethanePeptidesProteins

Identifiers

PMID36948184
PMCPMC10080679
OpenAlexW4353031856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.