Evidence map›Paper›PMID 36948112›Full record

ArticleParkinsonism & related disorders2023

Are you angry? Neural basis of impaired facial expression recognition in pre-manifest Huntington's.

H Diana Rosas, Lydia Lewis, Natalie Connors, Nathaniel D Mercaldo, Shahin Nasr

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

H Diana RosasAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA; Department of Radiology, Harvard Medical School, Boston, MA, 02115, USA; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA; Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, MA, 02129, USA. Electronic address: rosas@helix.mgh.harvard.edu.
Lydia LewisAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA; Department of Radiology, Harvard Medical School, Boston, MA, 02115, USA; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA; Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Natalie ConnorsAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA; Department of Radiology, Harvard Medical School, Boston, MA, 02115, USA; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA; Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Nathaniel D MercaldoAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA; Department of Radiology, Harvard Medical School, Boston, MA, 02115, USA; Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Shahin NasrDepartment of Radiology, Harvard Medical School, Boston, MA, 02115, USA; Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Huntington's Disease: Learning from ExtremesR01NS106384 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROSAS, HERMINIA DIANA · 2018 to 2022
$7.6M
Prospective Neuroimaging in Huntington's DiseaseR01NS042861 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROSAS, HERMINIA DIANA · 2003 to 2013
$5.6M
Understanding the Contribution of Altered Cerebrovascular Function to the Pathology and Clinical Symptoms of Huntington DiseaseR01NS114562 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HERMINIA Diana ROSAS · 2021 to 2026
$3.3M
Prospective Neuroimaging in Huntington's DiseaseR56NS042861 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ROSAS, HERMINIA DIANA · 2014 to 2014
$870k
NIBIB NIH HHS P41 EB015896NINDS NIH HHS R01 NS042861NINDS NIH HHS R01 NS106384NINDS NIH HHS R01 NS114562NINDS NIH HHS R56 NS042861
6 · The paper itself

Abstract

introductionEarly non-motor symptoms in Huntington's disease (HD), including visual perceptual difficulties, can have profound negative impacts on quality of life. In particular, deficits in emotion recognition may contribute to misinterpretation of social cues, and may adversely affect interpersonal relationships, work relationships and/or general well-being. This may be particularly salient during the pre-manifest period, a period prior to the onset of motor symptoms. We sought to evaluate impairments in emotion recognition in gene-positive individuals who did not meet criterial for a diagnosis of HD; we also sought to determine associations between emotion recognition processing and altered cortico-striatal circuitry.

methodsWe used a standardized battery to evaluate performance on a facial expression recognition task in a cohort of motor pre-manifest HD (Pre-HD) individuals (N = 21). Functional MRI (fMRI) was then used to assess the face processing network in a subset (N = 15).

resultsWe found significantly decreased response accuracy to certain facial expressions, particularly of negative emotions (p < 0.001) in Pre-HDs. When Pre-HDs viewed faces with different emotions, activation within the Superior Temporal Sulcus (fSTS) was reduced compared to controls; in contrast, the level of evoked response within other face-selective cortical regions was comparable.

conclusionEarly deficits in emotion recognition in Pre-HD appear to be associated with alterations in the fSTS response, a distinctly different pathway from that involved in face perception and provide support for early cognitive and behavioral interventions.

Indexed as

Facial RecognitionHuntington DiseaseEmotionsFacial ExpressionHumansQuality of LifeRecognition, PsychologyCognitive rehabilitationImpaired emotion processingPre-manifest Huntington's diseaseSuperior temporal sulcus

Identifiers

PMID36948112
PMCPMC11017071
OpenAlexW4320004459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.