Evidence map›Paper›PMID 36948092›Full record

ArticleMultiple sclerosis and related disorders2023

Spinal cord and brain corticospinal tract lesions are associated with motor progression in tumefactive multiple sclerosis.

Caitlin S Jackson-Tarlton, B Mark Keegan, Mahboubeh Fereidan-Esfahani, Benan O Barakat, Paul A Decker, Claudia F Lucchinetti, Jeanette Eckel-Passow, W Oliver Tobin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Caitlin S Jackson-TarltonDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Division of Neurology, Department of Medicine, Dalhousie University, Halifax, NS, USA.
B Mark KeeganDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Rochester, MN, USA.
Mahboubeh Fereidan-EsfahaniDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Division of Neurology, Department of Medicine, Dalhousie University, Halifax, NS, USA; Dell Medical School at the University of Texas at Austin, Austin, TX, USA.
Benan O BarakatDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Rochester, MN, USA; Department of Neurology, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, OH, USA.
Paul A DeckerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester MN, USA.
Claudia F LucchinettiDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Rochester, MN, USA.
Jeanette Eckel-PassowDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester MN, USA.
W Oliver TobinDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Rochester, MN, USA. Electronic address: tobin.oliver@mayo.edu.
Mayo Clinic · USMayo Clinic in Florida · USDalhousie University · CAMayo Clinic in Arizona · US

Funding

Diagnosis of indeterminate brain lesions using MRI-based machine learning and polygenic risk modelsR01NS113803 · NINDS · MAYO CLINIC ROCHESTER · PI ECKEL PASSOW, JEANETTE E, TOBIN, W. OLIVER · 2020 to 2024
$3.1M
NINDS NIH HHS R01 NS113803
6 · The paper itself

Abstract

backgroundSpinal cord lesions have been associated with progressive disease in individuals with typical relapsing remitting MS (RRMS).

objectiveIn the current study, we aimed to determine if progressive disease is associated with spinal cord lesions in those with tumefactive multiple sclerosis (MS).

methodsRetrospective chart review of individuals presenting to Mayo Clinic with tumefactive MS with spinal cord MRIs available (n=159). Clinical data were extracted by chart review. Brain and spinal cord MRIs were reviewed to characterize the tumefactive demyelinating lesion(s) and assess the burden of spinal cord disease.

resultsA total of 69 (43%) had spinal cord lesions. Progressive demyelinating disease was documented in 13 (8%); the majority (11/13) with secondary progressive disease. The method of progression was myelopathic in 8/13 (62%), cognitive in 3/13 (23%), motor from a supratentorial lesion in 2/13 (16%). EDSS at last follow-up was higher in those with progression than those without (median 6.0 (2.0-10.0) vs. 2.5 (0-10.0), p = < 0.001). Progressive demyelinating disease occurred in a minority.

conclusionsPatients with progression typically experienced progressive motor impairment, and this occurred exclusively in individuals with lesions in the corticospinal tracts of the brain and/or the spinal cord.

Indexed as

Multiple SclerosisSpinal Cord DiseasesBrainDisease ProgressionHumansMagnetic Resonance ImagingPyramidal TractsRetrospective StudiesSpinal CordCortical spinal tract lesionsEncephalopathyProgressive demyelinationRetrospective chart reviewTumefactive multiple sclerosis (TMS)

Identifiers

PMID36948092
PMCPMC12911108
OpenAlexW4323980898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.