Evidence map›Paper›PMID 36947664›Full record

ArticleAnalytical chemistry2023

Mass Spectrometry Approach for Differentiation of Positional Isomers of Saccharides: Toward Direct Analysis of Rare Sugars.

Enoch Amoah, Dmytro S Kulyk, Christopher S Callam, Christopher M Hadad, Abraham K Badu-Tawiah

Abstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Enoch AmoahDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Dmytro S KulykDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-0309-487X
Christopher S CallamDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-7655-2982
Christopher M HadadDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Abraham K Badu-TawiahDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0001-8642-3431

Funding

Integrating Accelerated Droplet Chemistry with LC-MS for High Throughput Quantitative AnalysisR01GM149080 · NIGMS · OHIO STATE UNIVERSITY · PI Abraham Badu-Tawiah · 2023 to 2026
$1.2M
NIGMS NIH HHS R01 GM149080
6 · The paper itself

Abstract

Rare sugars have gained popularity in recent years due to their use in antiaging treatments, their ability to sweeten with few calories, and their ability to heal infections. Rare sugars are found in small quantities in nature, and they exist typically as isomeric forms of traditional sugars, rendering some challenges in their isolation, synthesis, and characterization. In this work, we present the first direct mass spectrometric approach for differentiating structural isomers of sucrose that differ only by their glycosidic linkages. The method employed a noncontact nanoelectrospray (nESI) platform capable of analyzing minuscule volumes (5 μL) of saccharides via the formation of halide adducts ([M+X]

Indexed as

Spectrometry, Mass, Electrospray IonizationSugarsCarbohydratesGlycosidesIsomerismSucroseTandem Mass SpectrometryCarbohydratesGlycosidesSucroseSugars

Identifiers

PMID36947664
PMCPMC10696529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.