Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
22 authors at 7 institutions in 3 countries.
Shruti ApteDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.ORCID 0000-0003-0477-9667
Smita BhutdaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.ORCID 0000-0003-1090-4639
Sourav GhoshDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.ORCID 0000-0003-2070-4681
Kuldeep SharmaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.
Thomas E BartonDepartment of Clinical Infection, Microbiology and Immunology, University of Liverpool, L69 7BE Liverpool, UK.ORCID 0000-0002-4592-4261
Soham DibyachintanDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.ORCID 0000-0002-5247-9549
Osheen SahayCancer Biology and Epigenetics Laboratory, National Centre for Cell Science, Ganeshkhind Road, Pune 411007, Maharashtra, India.ORCID 0000-0001-5972-7632
Suvapriya RoyDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.
Akash Raj SinhaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.
Harikrishna AdicherlaCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500007 Telangana, India.ORCID 0000-0002-6107-2222
Jyotirmoy RakshitDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.ORCID 0000-0002-1432-9013
Shiying TangDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Akshay DateyDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, Karnataka, India.ORCID 0000-0002-8922-7847
Shweta SantraDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.
Jincy JosephDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.ORCID 0000-0002-4529-9144
Sreeja SasidharanDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.
Sven HammerschmidtDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute of Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, D-17487 Greifswald, Germany.ORCID 0000-0002-6382-6681
Dipshikha ChakravorttyDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560012, Karnataka, India.ORCID 0000-0002-7838-5145
Marco R OggioniDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.ORCID 0000-0003-4117-793X
Manas Kumar SantraCancer Biology and Epigenetics Laboratory, National Centre for Cell Science, Ganeshkhind Road, Pune 411007, Maharashtra, India.
Daniel R NeillDepartment of Clinical Infection, Microbiology and Immunology, University of Liverpool, L69 7BE Liverpool, UK.ORCID 0000-0002-7911-8153
Anirban BanerjeeDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Maharashtra, India.ORCID 0000-0002-4229-5981
Indian Institute of Technology Bombay · INIndian Institute of Science Bangalore · INNational Centre for Cell Science · INUniversity of Leicester · GBUniversity of Liverpool · GBCentre for Cellular and Molecular Biology · INUniversitätsmedizin Greifswald · DE
Funding
Wellcome Trust
6 · The paper itself
Abstract
Sensing of pathogens by ubiquitination is a critical arm of cellular immunity. However, universal ubiquitination targets on microbes remain unidentified. Here, using in vitro, ex vivo, and in vivo studies, we identify the first protein-based ubiquitination substrates on phylogenetically diverse bacteria by unveiling a strategy that uses recognition of degron-like motifs. Such motifs form a new class of intra-cytosolic pathogen-associated molecular patterns (PAMPs). Their incorporation enabled recognition of nonubiquitin targets by host ubiquitin ligases. We find that SCF
Indexed as
F-Box ProteinsBacteriaBacterial ProteinsCell Cycle ProteinsF-Box-WD Repeat-Containing Protein 7HumansMembrane ProteinsPhosphorylationUbiquitinationBacterial ProteinsCell Cycle ProteinsF-Box ProteinsF-Box-WD Repeat-Containing Protein 7Membrane Proteins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins. · full record | OpenQuestion