ArticlePLoS pathogens2023
Distinct function of SPL genes in age-related resistance in Arabidopsis.
Article in PLoS pathogens, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Evolution of virulence of a plant RNA virus in developmental stage-structured host populations.Molecular biology and evolution · 2026Article
- Squamosa promoter-binding protein-like 9 (SPL9) regulates age-dependent stem elongation and flowering in Lilium.Planta · 2026Article
- Evolutionary History, Transcriptome Expression Profiles, and Abiotic Stress Responses of theInternational journal of molecular sciences · 2026Article
- CaSBP12 is implicated in pepper's defense resistance to Phytophthora capsici infection associated with the SA signaling pathway.BMC plant biology · 2025Article
- Proline transporters balance the salicylic acid-mediated trade-off between regeneration and immunity in plants.bioRxiv : the preprint server for biology · 2025Article
- Leaf Developmental Stage Influences Disease Resistance in Tomato.Molecular plant pathology · 2025Article
- Regeneration and defense: unveiling the molecular interplay in plants.The New phytologist · 2025Review
- Ontogenetic changes in ecophysiology are an understudied yet important component of plant adaptation.American journal of botany · 2024Article
- Spatial regulation of immunity: unmasking the secrets of abaxial immunity to powdery mildew.Journal of experimental botany · 2024Article
- Temporal regulation of vegetative phase change in plants.Developmental cell · 2024Review
- Ontogenic stage-associated SA response contributes to leaf age-dependent resistance inFrontiers in plant science · 2024Article
- Pepper SBP-box transcription factor,Frontiers in plant science · 2024Article
- Shoot Maturation Strengthens FLS2-Mediated Resistance toMolecular plant-microbe interactions : MPMI · 2023Article
- The Homeodomain-Leucine Zipper Subfamily I Contributes to Leaf Age- and Time-Dependent Resistance to Pathogens inInternational journal of molecular sciences · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In plants, age-related resistance (ARR) refers to a gain of disease resistance during shoot or organ maturation. ARR associated with vegetative phase change, a transition from juvenile to adult stage, is a widespread agronomic trait affecting resistance against multiple pathogens. How innate immunity in a plant is differentially regulated during successive stages of shoot maturation is unclear. In this work, we found that Arabidopsis thaliana showed ARR against its bacterial pathogen Pseudomonas syringae pv. tomato DC3000 during vegetative phase change. The timing of the ARR activation was associated with a temporal drop of miR156 level. The microRNA miR156 maintains juvenile phase by inhibiting the accumulation and translation of SPL transcripts. A systematic inspection of the loss- and gain-of-function mutants of 11 SPL genes revealed that a subset of SPL genes, notably SPL2, SPL10, and SPL11, activated ARR in adult stage. The immune function of SPL10 was independent of its role in morphogenesis. Furthermore, the SPL10 mediated an age-dependent augmentation of the salicylic acid (SA) pathway partially by direct activation of PAD4. Disrupting SA biosynthesis or signaling abolished the ARR against Pto DC3000. Our work demonstrated that the miR156-SPL10 module in Arabidopsis is deployed to operate immune outputs over developmental timing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.