ArticlePloS one2023
Ongoing increasing trends in central precocious puberty incidence among Korean boys and girls from 2008 to 2020.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Postnatal Bisphenol A exposure and risk of precocious puberty in children: updated systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Global prevalence and incidence of precocious puberty: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Effect of Chinese herbal medicine on sexual characteristics of females with precocious puberty: a meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Meta-analysis of machine learning models for the diagnosis of central precocious puberty based on clinical, hormonal (laboratory) and imaging data.Frontiers in endocrinology · 2024Pooled it
- Rising incidence of central precocious puberty in Thailand: a nationwide population-based study before, during, and after the COVID-19 pandemic (2018-2024).Clinical and experimental pediatrics · 2026Article
- Development of a parsimonious predictive model for height gain outcome in children with central precocious puberty following gonadotropin-releasing hormone agonist therapy.Translational pediatrics · 2026Article
- Deep Learning-Based Bone Age Assessment for Predicting Final Adult Height in Girls With Central Precocious Puberty.Korean journal of radiology · 2026Article
- Correlation between ceramide and its metabolites and central precocious puberty: a cross-sectional study.BMC pediatrics · 2026Article
- Central precocious puberty in Türkiye, 2018-2024: national incidence, prevalence, and changes across the COVID-19 period.Frontiers in endocrinology · 2026Article
- Unveiling the gut: microbiota and derived metabolites' role in the rising tide of precocious puberty.Frontiers in microbiology · 2026Review
- Preventive Effects ofInternational journal of molecular sciences · 2025Article
- The incidence of early and precocious puberty of children in two Chinese cities: a multi-center prospective cohort study.BMC endocrine disorders · 2025Article
- Correlation analysis of pituitary morphometry in boys with idiopathic central precocious puberty or early puberty: implications for diagnosis.Translational pediatrics · 2025Article
- Is the triptorelin stimulation test comparable to the gonadorelin stimulation test in diagnosing central precocious puberty in boys?Annals of pediatric endocrinology & metabolism · 2025Article
- Diagnostic Value of Single LH and LH/FSH Ratio at 60-minute after GnRHa Stimulation Test for Central Precocious Puberty.Indian journal of pediatrics · 2025Article
- Breastfeeding, Prepubertal Adiposity, and Development of Precocious Puberty.JAMA network open · 2025Article
- Age-related insulin resistance changes in children and adolescents and its impact on the accuracy of diagnosis of metabolic syndrome.Annals of pediatric endocrinology & metabolism · 2025Article
- Differential impact of maternal and paternal metabolic syndrome on offspring's cardiometabolic risk factors.Scientific reports · 2025Article
- Hidden link between endocrine-disrupting chemicals and pediatric obesity.Clinical and experimental pediatrics · 2025Article
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the last few decades, there has been growing evidence of earlier onset and progression of puberty worldwide. This population-based longitudinal cohort study aimed to analyze the change in the annual incidence rate of central precocious puberty (CPP) among Korean children over the most recent decade, using the national registry data.
methodThe International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) and insurance claims for gonadotropin-releasing hormone agonist (GnRHa) treatment were used to identify CPP patients who were using the Korean Health Insurance Review & Assessment Service (HIRA) database between 2008 and 2020. Patients who began GnRHa therapy before the age of 9 and 10 for girls and boys, respectively, were included in the study.
resultsA total of 6,906 boys and 126,377 girls were diagnosed with CPP between 2008 and 2020. The annual incidence of CPP increased by 83.3 times in boys (from 1.2 to 100 per 100,000 persons) and by 15.9 times in girls (from 88.9 to 1414.7 per 100,000 persons). The age-specific annual incidence of CPP increased remarkably more in older children than in younger ones; the 2020 CPP incidence among 9-year-old boys and 8-year-old girls reached 705.2 and 7,967.3 per 100,000 persons, respectively. The annual prevalence of CPP in boys and girls increased from 2.7 to 206.5 (76.5 times) and from 141.8 to 3439.9 (24.3 times) per 100,000 persons, respectively.
conclusionBased on GnRHa treatment insurance claims, our study suggests that the annual incidence of CPP has substantially increased in Korea during the past 13 years. These findings highlight the importance of meticulous judgment by doctors in determining GnRHa treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.