ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2023
Anti-Oxidative and Anti-Aging Effects of Probiotic Fermented Ginseng by Modulating Gut Microbiota and Metabolites in Caenorhabditis elegans.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Strain-Dependent Fermentation Enhances the Bioactivity ofFoods (Basel, Switzerland) · 2026Article
- Anti-Tumor Activity of Stevia Leaf Extract Fermented by the Plant-DerivedAntioxidants (Basel, Switzerland) · 2026Article
- The role of fermented foods in healthy longevity: A review of potential anti-aging mechanisms.Current research in food science · 2026Review
- Targeting autophagy and programmed cell death in neurological diseases via probiotic intervention.Gut pathogens · 2025Review
- Physicochemical and Functional Characterization of Pearl Millet-Based Probiotic Beverage for Antiaging Potential inFoods (Basel, Switzerland) · 2025Article
- Microbiome-based therapeutics towards healthier aging and longevity.Genome medicine · 2025Review
- The role of ginseng in aging: Insights into regulatory T cells activation and mitochondrial regulation.Journal of ginseng research · 2025Review
- Mechanism of Red Yeast Rice in the Improvement of Atherosclerosis in Apolipoprotein E-deficient Mice Explored Through Metabolomics Combined with Serum Pharmacochemistry and Network Pharmacology.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Article
- The potential of medicinal food plantFrontiers in pharmacology · 2025Review
- Dietary purslane modulates gut microbiota and fecal metabolites in aging rats.Frontiers in microbiology · 2025Article
- A Comparison of the Impacts of Different Drying Methods on the Volatile Organic Compounds in Ginseng.Molecules (Basel, Switzerland) · 2024Article
- Research on the anti-aging mechanisms ofFrontiers in pharmacology · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antioxidative and antiaging abilities of probiotic fermented ginseng (PG) were evaluated in Caenorhabditis elegans (C. elegans). Lifespan and effect on heat stress and acute oxidative stress in C. elegans were significantly enhanced by PG. Antioxidative enzymes such as T-SOD, GSH-PX, CAT were significantly up-regulated, and MDA, ROS and apoptosis levels were significantly down-regulated. At the same time, PG exerted antioxidant and anti-aging activities by reducing the expression of DAF-2 mRNA and increasing the expression of SKN-1 and SOD-3 mRNA in C. elegans. In addition, the mechanism of antioxidative and antiaging activities of PG was explored through gut microbiota sequencing and untargeted metabolomics. The results of gut microbiota indicated that PG could significantly improve the composition and structure of microbes in the gut of C. elegans, and the relative abundance of beneficial bacteria was up-regulated. Untargeted metabolomic results elucidated that PG modulated antioxidant and antiaging activities through neuroactive ligand-receptor interaction, Citrate cycle (TCA cycle), pyruvate metabolism, ascorbate and aldarate metabolism and D-Arginine and D-ornithine metabolism of C. elegans. These results indicated that PG had excellent antioxidant and anti-aging activities, providing research value for the development of functional foods and improvement of aging-related diseases.
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