ReviewCurrent psychiatry reports2023
Is There an Inflammatory Profile of Perinatal Depression?
Review in Current psychiatry reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Pooled it
- The immune phenotype of perinatal anxiety in an anxiety-focused behavioral intervention program in Pakistan.Brain, behavior, and immunity · 2024Trial
- Examining the association between prenatal inflammation and postpartum depression in a large, prospective pregnancy cohort in New York City.Brain, behavior, and immunity · 2026Article
- The relationship between maternal adiposity during pregnancy and toddler ADHD symptoms is mediated by gestational inflammation.Brain, behavior, and immunity · 2026Article
- A review of the application of digital phenotyping in predicting peripartum depressive symptoms.NPJ digital medicine · 2026Article
- Inflammatory, clinical and sociodemographic factors associated with depressive disorder during pregnancy in Brazilian women.Scientific reports · 2026Article
- Peripartum Depression as a Heart-Brain-Endocrine-Immune Syndrome: Neuroendocrine, Cardiovascular, and Inflammatory Pathways Underlying Maternal Vulnerability.Life (Basel, Switzerland) · 2026Review
- Article
- Psychedelic therapy and postpartum depression: priorities and prospects.Therapeutic advances in psychopharmacology · 2026Review
- Associations between prenatal inflammation and dimensions of depressive symptoms across the perinatal period.Psychoneuroendocrinology · 2025Article
- Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum.Molecular psychiatry · 2025Article
- Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease.Expert review of clinical immunology · 2025Review
- Prenatal inflammation and trauma symptoms in Latina mothers: The role of discrimination and growing up in an ethnic minoritized context.Brain, behavior, & immunity - health · 2025Article
- Of scents and cytokines: How olfactory and food aversions relate to nausea and immunomodulation in early pregnancy.Evolution, medicine, and public health · 2025Article
- Construction of a predictive model for depressive symptoms following acute myocardial infarction and its impact on prognosis.Frontiers in psychiatry · 2025Article
- Bidirectional association between autoimmune disease and perinatal depression: a nationwide study with sibling comparison.Molecular psychiatry · 2024Article
- Risk of postpartum readmission for depression in relation to ischaemic placental disease: a population-based study.EClinicalMedicine · 2023Article
- Diet and the gut microbiota-immune axis in the context of perinatal mental health: Protocol for a prospective cohort study.Women's health (London, England)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewTo synthesize and critically examine recent evidence regarding associations between immune system activity and perinatal depression. RECENT
findingsDespite a significant number of studies assessing potential immunological markers of perinatal depression, it does not appear that levels of any individual pro- or anti-inflammatory marker is a useful predictor of perinatal depression. Some recent studies have observed differences in overall immune system functioning and adaptation across this period, taking into account multiple pro- and anti- inflammatory markers. Furthermore, there is evidence for interactions between depression and maternal psychosocial factors. Immune system functioning may be a mechanism through which social determinants of health contribute to risk for perinatal depression. There is substantial evidence implicating dysregulated immune activity in perinatal depression, yet little clarity regarding a consistent immune profile, especially based on analysis of circulating peripheral cytokines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.