Evidence map›Paper›PMID 36947224›Full record

ArticleSurgical endoscopy2023

Clinical outcomes and risk factors associated with poor prognosis after endoscopic resection of 10-20 mm rectal neuroendocrine tumors: a multicenter, retrospective study of 10-year experience.

Ja Jun Goo, Dong Hoon Baek, Hyung Wook Kim, Hong Sub Lee, Jong Yoon Lee, Su Bum Park, Geun Am Song, Sang Heon Lee, Jong Hoon Lee, Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ja Jun Goo *Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
Dong Hoon Baek *Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Hyung Wook KimDepartment of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea. mdkhwook@gmail.com.ORCID 0000-0002-2444-0591
Hong Sub LeeDepartment of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea.
Jong Yoon LeeDepartment of Internal Medicine, Dong-A University Hospital, Busan, Korea.
Su Bum ParkDepartment of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
Geun Am SongDepartment of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Sang Heon LeeDepartment of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea.
Jong Hoon LeeDepartment of Internal Medicine, Dong-A University Hospital, Busan, Korea.
Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)
Pusan National University Yangsan Hospital · KRDong-A University Hospital · KRInje University Busan Paik Hospital · KRPusan National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe efficacy of endoscopic resection for of 10-20 mm rectal neuroendocrine tumor (NET) remains controversial. We aimed to evaluate the clinical outcomes and risk factors associated with poor prognosis after endoscopic resection of 10-20 mm rectal NET and to determine the optimal treatment.

methodsPatients who underwent endoscopic resection for rectal NET in four tertiary hospitals were enrolled, and data on with the clinical outcomes and risk factors related to poor prognosis were retrospectively analyzed.

resultsA total of 105 patients who underwent endoscopic submucosal resection (ESD; n = 65, 61.9%), modified endoscopic mucosal resection (mEMR; n = 31, 29.5%), and conventional EMR (cEMR; n = 9, 8.6%) were enrolled. The mean follow-up period was 41.2 ± 21.9 months. In the morphologic findings, the mean diameter was 11.6 mm (range 10-19); the shape was sessile (50.5%) and mixed type (49.5%), and surface depression was observed in 41.9% of patients. In the histologic findings, 87.6% of patients had G1 and 12.4% G2 tumor grade, and 3.8% of patients had lymphovascular invasion. The overall en bloc and histologically complete (R0) resections were 99.1% and 76.2%, respectively. cEMR was a less-frequently developed R0 resection. In the univariate and multivariate analyses for R0 resection, only surface depression was significantly associated. Regional or distant organs metastasis during follow-up developed in three patients (2.9%) and was significantly associated with female sex, redness, G2 tumor grade, and non-ESD methods.

conclusionPatients who underwent endoscopic resection of 10-20 mm rectal NET had good prognosis; therefore, endoscopic resection can be considered as the first-line treatment, particularly for 10-14 mm rectal NET. However, the risk factors, such as female sex, redness, G2 tumor grade and non-ESD methods, were associated with regional or distant metastases during follow-up. Therefore, patients with these risk factors should be carefully monitored.

Indexed as

Endoscopic Mucosal ResectionNeuroendocrine TumorsRectal NeoplasmsFemaleHumansIntestinal MucosaRetrospective StudiesRisk FactorsTreatment OutcomeEndoscopic resectionNeuroendocrine tumorPrognosisRectum

Identifiers

PMID36947224
OpenAlexW4353018851

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.