Evidence map›Paper›PMID 36947193›Full record

SynthesisEuropean journal of clinical pharmacology2023

Analgesic potential of transdermal nicotine patch in surgery: a systematic review and meta-analysis of randomised placebo-controlled trials.

Davi da Silva Barbirato, Amanda Freire de Melo Vasconcelos, Sandra Lúcia Dantas de Moraes, Eduardo Piza Pellizzer, Belmiro Cavalcanti do Egito Vasconcelos

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Davi da Silva BarbiratoDivision of Oral and Maxillofacial Surgery, Dental School, University of Pernambuco (UPE), Arnóbio Marques St., 310, Recife, PE, 50100-130, Brazil.
Amanda Freire de Melo VasconcelosFederal University of Pernambuco (UFPE), Recife, PE, Brazil.
Sandra Lúcia Dantas de MoraesFaculty of Dentistry, University of Pernambuco (UPE), Camaragibe, PE, Brazil.
Eduardo Piza PellizzerDepartment of Dental Materials and Prosthodontics, São Paulo State University (UNESP), Araçatuba, Brazil.
Belmiro Cavalcanti do Egito VasconcelosDivision of Oral and Maxillofacial Surgery, Dental School, University of Pernambuco (UPE), Arnóbio Marques St., 310, Recife, PE, 50100-130, Brazil. belmiro.vasconcelos@upe.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed (1) to systematically review the efficacy of transdermal nicotine patches (NP) for postoperative analgesia, (2) to establish the current quality of evidence and assist clinical decision-making on the subject, and (3) to identify methodological limitations and the need for more well-designed studies. MATERIALS AND

methodsWe searched six electronic databases, protocol records, and other sources without date or language restriction until March 2022. To develop the search strategy, we formulated a clinical question by using the PICOD method. Eligibility criteria included randomised placebo-controlled trials on the analgesic potential of NP for surgical procedures. This systematic review followed the PRISMA 2020 statement, and we registered the protocol in PROSPERO (#CRD42020205956).

resultsWe included 10 randomised placebo-controlled trials (535 patients). The NP administered before induction of anaesthesia and at beginning of surgery reduced the pain immediately after surgery (-0.38; 95% confidence interval [CI]: -0.73 to -0.02), and 6 h (-0.34; 95% CI: -0.68 to -0.01), 12 h (-0.43; 95% CI: -0.71 to -0.15) and 24 h (-0.35; 95%CI: -0.59 to -0.10) after surgery, compared with the placebo patch (PP) group. Sensitivity testing suggests that opioid use could underestimate NP analgesia. Late demand for the first analgesic and consumption of rescue analgesics tended to be lower in the NP group.

conclusionsThe current findings suggest, with low certainty of evidence, the analgesic potential of NP for surgical procedures. CLINICAL RELEVANCE: Perioperative use of NP significantly improved postoperative pain, even when opioids were administered or prescribed. Nevertheless, the clinical relevance should be interpreted with caution, owing to the effect sizes of the summary measures and methodological issues. The analgesic potential of NP as an adjuvant therapy to regulate pain and acute inflammation may offer certain clinical advantages, thus warranting further investigation.

Indexed as

NicotineOpioid-Related DisordersAnalgesicsAnalgesics, OpioidHumansPostoperative PainRandomized Controlled Trials as TopicAnalgesicsAnalgesics, OpioidNicotineMeta-analysisNicotine patchOpioidsPain managementPerioperative periodPostoperative painPreoperative procedure

Identifiers

PMID36947193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.