Evidence map›Paper›PMID 36946840›Full record

ReviewBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2023

Oxidative stress and inflammatory process in borderline personality disorder (BPD): a narrative review.

A R C C Forte, P H C Lessa, A J M Chaves Filho, P E A de Aquino, L M Brito, L C Pinheiro, M F Juruena, D F de Lucena, P H F de Rezende, S M M de Vasconcelos

Open access · goldFull text readReview
In one paragraph

Review in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Anxiety and nonpsychotic mental disorders in acute urticaria.Brain, behavior, & immunity - health · 2025
    Article
  6. Personality and Psychoneuroimmunology: A Systems Biology Perspective.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

A R C C ForteLaboratório de Neuropsicofarmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-5143-6918
P H C LessaCurso de Medicina, Departamento de Ciências Biológicas e da Saúde (DCBS), Universidade Federal do Amapá, Macapá, AP, Brasil.ORCID http://orcid.org/0000-0002-2499-6936
A J M Chaves FilhoLaboratório de Neuropsicofarmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0003-1018-0431
P E A de AquinoLaboratório de Neuropsicofarmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-4756-081X
L M BritoLaboratório de Neuropsicofarmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-9385-1570
L C PinheiroLaboratório de Neuropsicofarmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0003-4003-9527
M F JuruenaInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-8558-3396
D F de LucenaLaboratório de Neuropsicofarmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-1547-3711
P H F de RezendeLaboratório de Neuropsicofarmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-6252-7698
S M M de VasconcelosLaboratório de Neuropsicofarmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0003-1478-0127
Universidade Federal do Ceará · BRKing's College London · GBUniversidade Federal do Amapá · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Borderline personality disorder (BPD) is a severe psychiatric condition that affects up to 2.7% of the population and is highly linked to functional impairment and suicide. Despite its severity, there is a lack of knowledge about its pathophysiology. Studies show genetic influence and childhood violence as factors that may contribute to the development of BPD; however, the involvement of neuroinflammation in BPD remains poorly investigated. This article aimed to explore the pathophysiology of BPD according to the levels of brain-derived neurotrophic factor (BDNF), inflammatory cytokines, and oxidative stress substances that exacerbate neuronal damage. Few articles have been published on this theme. They show that patients with BPD have a lower level of BDNF and a higher level of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in peripheral blood, associated with increased plasma levels of oxidative stress markers, such as malondialdehyde and 8-hydroxy-2-deoxyguanosine. Therefore, more research on the topic is needed, mainly with a pre-clinical and clinical focus.

Indexed as

Borderline Personality DisorderBrain-Derived Neurotrophic FactorChildHumansInterleukin-6Tumor Necrosis Factor-alphaBrain-Derived Neurotrophic FactorInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID36946840
PMCPMC10021502
OpenAlexW4328023971

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read18
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.