Evidence map›Paper›PMID 36946697›Full record

ArticleeLife2023

Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in

Hilary Scott, Boris Novikov, Berrak Ugur, Brooke Allen, Ilya Mertsalov, Pedro Monagas-Valentin, Melissa Koff, Sarah Baas Robinson, Kazuhiro Aoki, Raisa Veizaj and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Sialylation in the nervous system: Functions and mechanisms.The Journal of biological chemistry · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Hilary Scott *Department of Biochemistry and Biophysics, Texas A&M University, College Station, United States.
Boris Novikov *Department of Biochemistry and Biophysics, Texas A&M University, College Station, United States.ORCID 0009-0007-0458-8445
Berrak UgurDepartments of Molecular and Human Genetics and Neuroscience, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.ORCID 0000-0003-4806-8891
Brooke AllenDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, United States.
Ilya MertsalovDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, United States.
Pedro Monagas-ValentinDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, United States.
Melissa KoffDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, United States.
Sarah Baas RobinsonComplex Carbohydrate Research Center, University of Georgia, Athens, United States.
Kazuhiro AokiComplex Carbohydrate Research Center, University of Georgia, Athens, United States.
Raisa VeizajTranslational Metabolic Laboratory, Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands.
Dirk J LefeberTranslational Metabolic Laboratory, Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, Netherlands.
Michael TiemeyerComplex Carbohydrate Research Center, University of Georgia, Athens, United States.
Hugo BellenDepartments of Molecular and Human Genetics and Neuroscience, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.ORCID 0000-0001-5992-5989
Vladislav PaninDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, United States.ORCID 0000-0001-9126-1481
Texas A&M University · USUniversity of Georgia · USBaylor College of Medicine · USRadboud University Nijmegen · NLKoltzov Institute of Developmental Biology · RUMassachusetts Eye and Ear Infirmary · US

Funding

TR&D1: Stem Cell and Induced Pluripotent Stem Cell Resources (Pages 116-134)P41GM103490 · NIGMS · UNIVERSITY OF GEORGIA · PI PIERCE, J. MICHAEL · 2012 to 2018
$13.7M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Functional mechanisms underlying Dystroglycan-dependent and independent roles of protein O-mannosylation in the nervous systemR01NS099409 · NINDS · TEXAS A&M AGRILIFE RESEARCH · PI PANIN, VLADISLAV M · 2017 to 2021
$1.6M
The control of neural transmission by glycosylationR01NS075534 · NINDS · TEXAS A&M UNIVERSITY · PI PANIN, VLADISLAV M · 2011 to 2015
$1.6M
IMSD at Texas A&M University: Initiative for Maximizing Student Diversity in Biomedical SciencesT32GM135748 · NIGMS · TEXAS A&M UNIVERSITY · PI BRINKMEYER-LANGFORD, CANDICE L., CHIU, WEIHSUEH A · 2020 to 2024
$1.2M
The role of sialylation in glia-neuron communications and stress responsesR56NS129122 · NINDS · TEXAS A&M AGRILIFE RESEARCH · PI PANIN, VLADISLAV M · 2023 to 2023
$364k
NIGMS NIH HHS P41 GM103490NIGMS NIH HHS T32 GM135748NIH HHS P40 OD018537NINDS NIH HHS R01 NS075534NINDS NIH HHS R01 NS099409NINDS NIH HHS R56 NS129122
6 · The paper itself

Abstract

Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. Sialylation relies on a dedicated pathway involving evolutionarily conserved enzymes, including CMP-sialic acid synthetase (CSAS) and sialyltransferase (SiaT) that mediate the activation of sialic acid and its transfer onto glycan termini, respectively. In

Indexed as

DrosophilaNervous System Physiological PhenomenaAnimalsNeurogliaNeuronsPolysaccharidesSynaptic TransmissionPolysaccharidesbiochemistrychemical biologyD. melanogasterglycosylationneuron-glia interactionsneuroscienceoxidative stresssialylationsialyltransferasevoltage-gated sodium channel

Identifiers

PMID36946697
PMCPMC10110239
OpenAlexW4353015285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.