Evidence map›Paper›PMID 36946544›Full record

ArticleCell transplantation

Notch Signaling-Modified Mesenchymal Stem Cell Patch Improves Left Ventricular Function via Arteriogenesis Induction in a Rat Myocardial Infarction Model.

Shusaku Maeda, Takuji Kawamura, Dai Chida, Kazuo Shimamura, Koichi Toda, Akima Harada, Yoshiki Sawa, Shigeru Miyagawa

Open access · goldAbstract read
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shusaku MaedaDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Takuji KawamuraDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Dai ChidaSanBio, Inc., Tokyo, Japan.
Kazuo ShimamuraDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Koichi TodaDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Akima HaradaDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Yoshiki SawaDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Shigeru MiyagawaDepartment of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0003-4498-207X
The University of Osaka · JPSanBio (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For ischemic cardiomyopathy (ICM) with limited therapeutic options, the induction of arteriogenesis has the potential to improve cardiac function through major restoration of blood flow. We hypothesized that transplantation of a Notch signaling-modified mesenchymal stem cell (SB623 cell) patch would induce angiogenesis and arteriogenesis in ischemic lesions, leading to improvement of left ventricular (LV) function in a rat ICM model. Two weeks after the induction of ischemia, SB623 cell patch transplantation into ICM rats (SB group,

Indexed as

Mesenchymal Stem CellsMyocardial InfarctionMyocardial IschemiaAnimalsIschemiaNeovascularization, PhysiologicRatsVentricular Function, Leftvon Willebrand Factorvon Willebrand Factorarteriogenesiscell therapygene modificationischemic cardiomyopathyNotch signaling

Identifiers

PMID36946544
PMCPMC10037722
OpenAlexW4353021325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.