Evidence map›Paper›PMID 36946440›Full record

ArticleEuropean journal of haematology2023

Relationships between T-lymphocytes and physical function in adults with chronic lymphocytic leukemia: Results from the HEALTH4CLL pilot study.

Justin C Crane, Max J Gordon, Karen Basen-Engquist, Alessandra Ferrajoli, Melissa M Markofski, Che Young Lee, Sara Fares, Richard J Simpson, Emily C LaVoy

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of haematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02194387 (Pilot Tests to Optimize the Delivery of Energy Balance Interventions), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02194387 naactive not recruitingnot on this map

Pilot Tests to Optimize the Delivery of Energy Balance Interventions

TypeinterventionalSponsorM.D. Anderson Cancer CenterRan2014 to 2027Enrolled337ConditionsBody Mass Index 25 or Greater, BRCA1 Gene Mutation, BRCA2 Gene Mutation, Breast CarcinomaArmsDietary Intervention, Internet-Based Intervention, Laboratory Biomarker Analysis, Questionnaire Administration, Telephone-Based Intervention
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Justin C CraneDepartment of Health and Human Performance, University of Houston, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-6144-4412
Max J GordonThe University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-3940-4451
Karen Basen-EngquistThe University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-7299-0646
Alessandra FerrajoliThe University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-9547-4193
Melissa M MarkofskiDepartment of Health and Human Performance, University of Houston, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-0214-4246
Che Young LeeThe University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-4998-3573
Sara FaresThe University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-3559-3358
Richard J SimpsonSchool of Nutritional Sciences and Wellness, The University of Arizona, Tucson, Arizona, USA.ORCID https://orcid.org/0000-0002-7064-6881
Emily C LaVoyDepartment of Health and Human Performance, University of Houston, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-9505-0144

Funding

TRAINING FOR ACADEMIC ONCOLOGY/HEMATOLOGYT32CA009666 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Michael Davies, Courtney DiNardo · 1994 to 2026
$9.8M
NCI NIH HHS T32 CA009666
6 · The paper itself

Abstract

objectiveExamine physical function and T-cell phenotype in patients with chronic lymphocytic leukemia (CLL) before and after a physical activity (PA) intervention.

methodsPhysical function measures and blood samples were collected from CLL patients (Rai stage 0-4, 50% receiving targeted therapy, N = 24) enrolled in a 16-week intervention of at-home aerobic and/or resistance exercise. Flow cytometry characterized T-cells in cryopreserved peripheral blood cells. Wilcoxon signed-rank test compared physical function and T-cell phenotype at baseline and 16-weeks; Kendall's Tau assessed associations between variables.

resultsGodin leisure-time PA score increased from baseline to 16-weeks (mean difference: 14.61, p < .01) and fatigue decreased (mean difference: 6.71, p < .001). At baseline, lower fatigue correlated with a lower proportion of CD8+ T-cells (τ = 0.32, p = .03) and cardiorespiratory fitness (CRF) inversely correlated with the percentage of PD-1+CD8+ T-cells (τ -0.31, p = .03). At 16-weeks, CRF inversely correlated with the proportion of PD-1+CD4+ T-cells (τ -0.34, p = .02). Reduced fatigue at 16-weeks correlated with an increased CD4:CD8 ratio (τ = 0.36, p = .02) and lower percentage of HLA-DR+PD-1+CD4+ T-cells (τ = -0.37, p = .01).

conclusionsThis intervention increased leisure-time PA and decreased fatigue in CLL patients. These changes correlated with an increased CD4:CD8 T-cell ratio and reduced proportion of T-cells subsets previously associated with poor outcomes in CLL patients.

trial registrationClinicalTrials.gov Identifier: NCT02194387.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFatigueHumansPilot ProjectsProgrammed Cell Death 1 ReceptorProgrammed Cell Death 1 Receptorcancerexercisefatigueimmunelymphomaphysical activityT cell

Identifiers

PMID36946440
PMCPMC10929688

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.