Evidence map›Paper›PMID 36946433›Full record

ArticleACS infectious diseases2023

Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies.

Henrietta D Attram, Constance M Korkor, Dale Taylor, Mathew Njoroge, Kelly Chibale

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Henrietta D AttramDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Constance M KorkorDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0001-6925-8905
Dale TaylorDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Mathew NjorogeDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0003-1276-2224
Kelly ChibaleDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0002-1327-4727
University of Cape Town · ZASouth African Medical Research Council · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously identified a novel class of antimalarial benzimidazoles incorporating an intramolecular hydrogen bonding motif. The frontrunner of the series, analogue

Indexed as

AntimalarialsFolic Acid AntagonistsChemistry, PharmaceuticalHemeHydrogen BondingImidazolesMolecular Docking SimulationPlasmodium falciparumPyridinesAntimalarialsFolic Acid AntagonistsHemeImidazolesimidazopyridinePyridinesheme fractionationimidazopyridinesintramolecular hydrogen bondinglive-cell microscopyPlasmodium falciparum

Identifiers

PMID36946433
PMCPMC10111423
OpenAlexW4353016837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.