ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2023
[A preliminary study on the role of V-domain Ig suppressor of T cell activation in juvenile idiopathic arthritis].
Li-Ping Xiao, Li-Na Zhou, Jun-Jie Chen, Yan Zhang, Xue-Mei Tang, Juan Zhou
Open access · greenAbstract readEnglish Abstract
In one paragraphArticle in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors at 1 institution in 1 country.
Li-Ping XiaoDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Child Infection and Immunity/Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.
Li-Na ZhouDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Child Infection and Immunity/Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.
Jun-Jie ChenDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Child Infection and Immunity/Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.
Yan ZhangDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Child Infection and Immunity/Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.
Xue-Mei TangDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Child Infection and Immunity/Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.
Juan ZhouDepartment of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Child Infection and Immunity/Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China.
China International Science and Technology Cooperation · CN
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No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
objectivesTo study the expression of V-domain Ig suppressor of T cell activation (VISTA) in peripheral blood of children with juvenile idiopathic arthritis (JIA) and its role in the pathogenesis of JIA.
methodsIn this prospective study, peripheral blood was collected from 47 children with different subtypes of JIA and 10 healthy children. Flow cytometry was used to measure the expression levels of VISTA, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α) on CD14
resultsThe children with JIA had a significantly lower expression level of VISTA than the healthy children (
conclusionsThe insufficient expression of VISTA may be associated with the pathogenesis of JIA, and enhancing the immunomodulatory effect of VISTA might be one option for the treatment of JIA in the future.
Indexed as
Arthritis, JuvenileCD8-Positive T-LymphocytesChildHumansInterferon-gammaProspective StudiesTumor Necrosis Factor-alphaInterferon-gammaTumor Necrosis Factor-alphaChildJuvenile idiopathic arthritisLymphocyteMonocyteV-domain Ig suppressor of T cell activation
Identifiers
PMID36946162
PMCPMC10032065
OpenAlexW4353014965
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