ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2023
[A pilot study on the effects of early use of valproate sodium on neuroinflammation after traumatic brain injury].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- The Role of Interleukins in Pediatric Traumatic Brain Injury: A Narrative Synthesis.Journal of clinical medicine · 2025Review
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6 authors at 1 institution in 1 country.
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Abstract
objectivesTo study the effect of early use of sodium valproate on neuroinflammation after traumatic brain injury (TBI).
methodsA total of 45 children who visited in Xuzhou Children's Hospital Affiliated to Xuzhou Medical University from August 2021 to August 2022 were enrolled in this prospective study, among whom 15 healthy children served as the healthy control group, and 30 children with TBI were divided into a sodium valproate treatment group and a conventional treatment group using a random number table (
resultsCompared with the healthy control group, the children with TBI had significantly higher serum concentrations of NLRP3, HMGB1, TNF-α, and IL-1β on day 1 after admission (
conclusionsEarly use of sodium valproate can reduce the release of neuroinflammatory factors and improve the prognosis of children with TBI.
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