Evidence map›Paper›PMID 36946148›Full record

ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2023

Genetic analyses of chr11p15.5 region identify

Xingnan Li, Huashi Li, Stephanie A Christenson, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Benjamin M Gaston, Elliot Israel, Nizar N Jarjour and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Genome-wide Association Study IdentifiesAllergy, asthma & immunology research · 2026
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 11 institutions in 1 country.

Xingnan LiDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-1208-8658
Huashi LiDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Stephanie A ChristensonDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Mario CastroDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kansas School of Medicine, Kansas City, KS, USA.
Loren C DenlingerDepartment of Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
Serpil C ErzurumLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
John V FahyDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Benjamin M GastonWells Center for Pediatric Research and Riley Hospital for Children, Indiana University, Indianapolis, IN, USA.
Elliot IsraelDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nizar N JarjourDepartment of Medicine, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9515-5731
David T MaugerDepartment of Public Health Sciences, College of Medicine, Penn State University, Hershey, PA, USA.
Wendy C MooreDepartment of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Joe ZeinLerner Research Institute and the Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
Naftali KaminskiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Sally E WenzelDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Eugene R BleeckerDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Deborah A MeyersDivision of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
NHLBI Severe Asthma Research Program (SARP)
University of Arizona · USUniversity of California, San Francisco · USBrigham and Women's Hospital · USCleveland Clinic Lerner College of Medicine · USUniversity of Wisconsin–Madison · USPennsylvania State University · USRiley Hospital for Children · USUniversity of Kansas · USUniversity of Pittsburgh · USWake Forest University · USYale University · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle · 2008 to 2026
$41.1M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 2012 to 2023
$23.3M
ZOSUQUIDAR TRIHYDROCHLORIDE IN NEWLY DIAGNOSED AMLM01RR003186 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI TRAYNOR, ANNE M · 1986 to 2007
$19.3M
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002373NCATS NIH HHS UL1 TR002378NCRR NIH HHS M01 RR003186NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR018390NCRR NIH HHS UL1 RR024992NHLBI NIH HHS K08 HL133381NHLBI NIH HHS K24 HL137013NHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL069116NHLBI NIH HHS R01 HL069130NHLBI NIH HHS R01 HL069149NHLBI NIH HHS R01 HL069155NHLBI NIH HHS R01 HL069167NHLBI NIH HHS R01 HL069170NHLBI NIH HHS R01 HL069174NHLBI NIH HHS R01 HL069349NHLBI NIH HHS R01 HL087665NHLBI NIH HHS R01 HL091762NHLBI NIH HHS R01 HL142769NHLBI NIH HHS RC2 HL101487NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10 HL109257NIAID NIH HHS R01 AI149754NIAID NIH HHS U19 AI077439
6 · The paper itself

Abstract

objectiveGenome-wide association studies (GWASs) have identified single nucleotide polymorphisms (SNPs) in chr11p15.5 region associated with asthma and idiopathic interstitial pneumonias (IIPs). We sought to identify functional genes for asthma by combining SNPs and mRNA expression in bronchial epithelial cells (BEC) in the Severe Asthma Research Program (SARP).

methodsCorrelation analyses of mRNA expression of six candidate genes (

resultsHigher expression of

conclusionsSNPs associated with asthma in chr11p15.5 region are not associated with asthma severity neither with IIPs. Higher expression of

Indexed as

AsthmaCross-Sectional StudiesGenome-Wide Association StudyHumansMucin 5ACMucin-5BPhenotypeRNA, MessengerMUC5AC protein, humanMUC5B protein, humanMucin 5ACMucin-5BRNA, Messengerasthma severityAsthma susceptibilityeQTLgene expressiongenetic associationMUC5ACMUC5B

Identifiers

PMID36946148
PMCPMC10524756
OpenAlexW4353020735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.