Evidence map›Paper›PMID 36946064›Full record

ArticlePhysiological reports2023

Mice with endothelial cell-selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction.

Vadym Buncha, Katie Anne Fopiano, Liwei Lang, Celestine Williams, Anatolij Horuzsko, Jessica Andrea Filosa, Gaston Kapuku, Zsolt Bagi

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Molecular Mechanisms Governing Vascular Function in Heart Failure.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Vadym BunchaDepartment of Physiology, Medical College of Georgia, Augusta University, Georgia, Augusta, USA.
Katie Anne FopianoDepartment of Physiology, Medical College of Georgia, Augusta University, Georgia, Augusta, USA.
Liwei LangDepartment of Physiology, Medical College of Georgia, Augusta University, Georgia, Augusta, USA.
Celestine WilliamsDepartment of Medicine, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Anatolij HoruzskoGeorgia Cancer Center, Medical College of Georgia, Augusta University, Georgia, Augusta, USA.
Jessica Andrea FilosaDepartment of Physiology, Medical College of Georgia, Augusta University, Georgia, Augusta, USA.
Gaston KapukuDepartment of Medicine, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Zsolt BagiDepartment of Physiology, Medical College of Georgia, Augusta University, Georgia, Augusta, USA.ORCID 0000-0001-8755-2980
Augusta University · US

Funding

Oligodendrocyte Progenitors and Hyaluronan-mediated Mechanisms of Human Vascular White Matter InjuryRF1AG065406 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BACK, STEPHEN ARTHUR · 2020 to 2020
$2.9M
TACE and Clock mechanisms in aging and vascular stiffeningR01AG054651 · NIA · AUGUSTA UNIVERSITY · PI BAGI, ZSOLT, RUDIC, RADU DANIEL · 2017 to 2021
$2.6M
Oligodendrocyte Progenitors and Hyaluronan-mediated Mechanisms of Human Vascular White Matter InjuryR01AG065406 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI BACK, STEPHEN ARTHUR · 2024 to 2024
$667k
American Heart Association-American Stroke Association 917057NIA NIH HHS R01 AG054651NIA NIH HHS R01AG054651NIA NIH HHS R01 AG065406NIA NIH HHS RF1 AG065406
6 · The paper itself

Abstract

Endothelial cell-selective adhesion molecule (ESAM) regulates inflammatory cell adhesion and transmigration and promotes angiogenesis. Here, we examined the role of ESAM in cardiac vascularization, inflammatory cell infiltration, and left ventricle (LV) diastolic function under basal and hemodynamic stress conditions. We employed mice with homozygous genetic deletion of ESAM (ESAM

Indexed as

Microvascular RarefactionVentricular Dysfunction, LeftAnimalsDiastoleEndothelial CellsHeartHeart VentriclesMiceVentricular Function, Leftangiogenesiscoronarydiastolic dysfunctionHFpEFinflammation

Identifiers

PMID36946064
PMCPMC10031300
OpenAlexW4353015508

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read22
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.