Evidence map›Paper›PMID 36946053›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Inducible co-stimulatory molecules participate in mesenteric vascular endothelial-mesenchymal transition and sclerosis of mesenteric vessels in spontaneously hypertensive rats].

C DU, Y Wang, J Fu, D Cao, R Mei, Q Zhang

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

C DUDepartment of Medical Functional Sciences, Medical College, Anhui University of Science and Technology, Huainan 232001, China.
Y WangDepartment of Medical Functional Sciences, Medical College, Anhui University of Science and Technology, Huainan 232001, China.
J FuDepartment of Medical Functional Sciences, Medical College, Anhui University of Science and Technology, Huainan 232001, China.
D CaoDepartment of Medical Functional Sciences, Medical College, Anhui University of Science and Technology, Huainan 232001, China.
R MeiDepartment of Medical Functional Sciences, Medical College, Anhui University of Science and Technology, Huainan 232001, China.
Q ZhangDepartment of Medical Functional Sciences, Medical College, Anhui University of Science and Technology, Huainan 232001, China.
Anhui University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the correlation of inducible co-stimulatory molecules (ICOS) with mesenteric vascular endothelial- mesenchymal transition (EndMT) and sclerosis in spontaneously hypertensive rats (SHR).

methodsTwenty 4-week-old WKY rats and 20 SHRs of the same strain were both randomly divided into 4 groups for observation at 4, 6, 10 and 30 weeks of age. ICOS expression frequency in rat spleen CD4

resultsCompared with the control WKY rats, the SHRs began to show significantly increased systolic blood pressure and ICOS expression frequency on CD4

conclusionICOS play an important pathogenic role in EndMT and sclerosis of mesenteric vessels in essential hypertension by mediating related immune responses.

Indexed as

HypertensionAnimalsBlood PressureInterleukin-17MesenteryRatsRats, Inbred SHRRats, Inbred WKYRNA, MessengerSclerosisTransforming Growth Factor betaInterleukin-17RNA, MessengerTransforming Growth Factor betaendothelial-mesenchymal transitionhypertensioninducible co-stimulatory moleculesvascular sclerosis

Identifiers

PMID36946053
PMCPMC10034542
OpenAlexW4353021335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.