Evidence map›Paper›PMID 36946034›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[LASS2/TMSG1 overexpression inhibits proliferation and promotes apoptosis of human lung cancer A549 cells possibly by upregulating ceramide and p38 MAPK to activate a signaling cascade].

Z Liu, C Xuan, X Han, Z Zheng, R Xiao, L Bao, X Xu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Z LiuCollege of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010059, China.
C XuanCollege of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010059, China.
X HanCollege of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010059, China.
Z ZhengCollege of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010059, China.
R XiaoCollege of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010059, China.
L BaoCollege of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010059, China.
X XuCollege of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010059, China.
Inner Mongolia Medical University · CNQingdao Huanghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of LASS2/TMSG1 gene overexpression on proliferation and apoptosis of human lung cancer A549 cells and explore the possible mechanism.

methodsWe examined LASS2/TMSG1 expression level in a previously constructed A549 cell line overexpressing LASS2/TMSG1 using Western blotting. The proliferation and apoptosis of the cells were detected using colony-forming assay, CCK-8 assay, Hoechst/PI double staining and flow cytometry. Fourteen nude mice were randomized into 2 groups (

resultsCompared with the negative control cells, A549 cells with LASS2/TMSG1 overexpression had significantly lowered proliferation ability

conclusionOverexpression of LASS2/TMSG1 gene can significantly inhibit the proliferation and promote early apoptosis of human lung cancer A549 cells both

Indexed as

Lung Neoplasmsp38 Mitogen-Activated Protein KinasesA549 CellsAnimalsApoptosisCell Line, TumorCell ProliferationHumansMembrane ProteinsMiceMice, NudeSignal TransductionSphingosine N-AcyltransferaseTumor Suppressor ProteinsCERS2 protein, humanCers2 protein, mouseMembrane Proteinsp38 Mitogen-Activated Protein KinasesSphingosine N-AcyltransferaseTumor Suppressor ProteinsapoptosisceramideLASS2/TMSG1lung cancerp38 MAPKproliferation

Identifiers

PMID36946034
PMCPMC10034540
OpenAlexW4353021327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.