ArticleTurkish journal of medical sciences2022
Causes of severe infections in patients with systemic sclerosis and associated factors.
Article in Turkish journal of medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 7 citations in OpenAlex.
- Infectious comorbidities in pregnant patients with rheumatic diseases.Rheumatology international · 2026Review
- Application of the Scleroderma Clinical Trials Consortium Damage Index in patients with juvenile systemic sclerosis.Pediatric rheumatology online journal · 2025Article
- Systemic Sclerosis Presenting as Osteomyelitis of the Finger: Physicians Must Maintain a High Index of Suspicion for Systemic Sclerosis when Evaluating Patients with Fingertip Ulceration or Infection.Journal of orthopaedic case reports · 2025Article
- Characteristics and management of systemic sclerosis-related osteomyelitis: a retrospective cohort study.Rheumatology international · 2025Article
- Preliminary nomogram model for predicting irreversible organ damage of patients with systemic sclerosis.Rheumatology (Oxford, England) · 2025Article
- Systemic Sclerosis Complicated by Rapidly Progressive Osteomyelitis: A Case Report.Current rheumatology reviews · 2025Article
- Review
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSystemic sclerosis (SSc) is a chronic systemic disease characterized by vascular damage, autoimmunity, and fibrosis in the skin and internal organs. In this study, we tried to determine the causes of severe infection in patients with SSc and to reveal the factors associated with severe infection.
methodsWe retrospectively examined 214 SSc patients between January 2010 and August 2020. Forty-seven patients with at least one severe infection and 167 patients without severe infection were compared.
resultsA total of 76 episodes of severe infections were detected in 47 (22%) patients. Common infections included pneumonia, infected digital ulcer, urinary tract infections, and osteomyelitis. Female patients had a higher frequency in the group without severe infection (91.6% vs. 80.9%, p = 0.035). Patients with severe infections had a higher frequency of digital ulcers (p < 0.001), cardiac (p = 0.002), and GIS involvement (p < 0.001). In multivariable analysis, digital ulcer presence (OR: 2.849 [1.356-5.898] (p = 0.006) and cardiac involvement (OR: 2.801 [1.248-6.285]) were associated with severe infection. Of the patients with severe infections, 34% had recurrent severe infections. There was no difference in demographic and clinical characteristics between patients with recurrent and nonrecurrent severe infections. DISCUSSION: The presence of digital ulcer and cardiac involvement seem to be associated with a severe infection in patients with systemic sclerosis. In patients with cardiac involvement and digital ulcers, more careful attention may be required for the development of severe infections.
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