Evidence map›Paper›PMID 36945684›Full record

ArticleFrontiers in thermal engineering2023

Design of a temperature-feedback controlled automated magnetic hyperthermia therapy device.

Anirudh Sharma, Avesh Avinash Jangam, Julian Low Yung Shen, Aiman Ahmad, Nageshwar Arepally, Hayden Carlton, Robert Ivkov, Anilchandra Attaluri

Open access · diamondFull text read
In one paragraph

Article in Frontiers in thermal engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Verification and validation in canine cadaver of an MPI-integrable RF head coil for magnetic particle hyperthermia.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
    Article
  2. Design, verification and validation of a spatially confined magnetic nanoparticle thermal therapy device for conformal thermal dose contouring.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
    Article
  3. Feasibility of thermal dose painting during magnetic nanoparticle thermal therapy: a computational analysis.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026
    Article
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  7. HYPER: pre-clinical device for spatially-confined magnetic particle hyperthermia.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anirudh SharmaDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Avesh Avinash JangamDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA, United States.
Julian Low Yung ShenDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA, United States.
Aiman AhmadDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA, United States.
Nageshwar ArepallyDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA, United States.
Hayden CarltonDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Robert IvkovDepartment of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Anilchandra AttaluriDepartment of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA, United States.
Pennsylvania State University · USJohns Hopkins Medicine · US

Funding

Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for GlioblastomaR01CA247290 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HADJIPANAYIS, CONSTANTINOS GEORGE, IVKOV, ROBERT · 2020 to 2024
$3.5M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
dMRI-guided pre-operative planning for supra-total resection of high-gradegliomasR01CA278819 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Michele Renee Aizenberg, Constantinos George Hadjipanayis · 2023 to 2026
$3.2M
NCI NIH HHS R01 CA247290NCI NIH HHS R01 CA257557NCI NIH HHS R01 CA278819
6 · The paper itself

Abstract

Introduction: Magnetic hyperthermia therapy (MHT) is a minimally invasive adjuvant therapy capable of damaging tumors using magnetic nanoparticles exposed radiofrequency alternating magnetic fields. One of the challenges of MHT is thermal dose control and excessive heating in superficial tissues from off target eddy current heating. Methods: We report the development of a control system to maintain target temperature during MHT with an automatic safety shutoff feature in adherence to FDA Design Control Guidance. A proportional-integral-derivative (PID) control algorithm was designed and implemented in NI LabVIEW Results: Results showed that the PID controller successfully achieved the target temperature control despite significant perturbations. Discussion and Conclusion: Feasibility of PID control algorithm to improve efficacy and safety of MHT was demonstrated.

Indexed as

FDA-food and drug administrationfinite element analysismagnetic hyperthermia therapyproportional-integral-derivative (PID) controlsafetytemperature controlverification

Identifiers

PMID36945684
PMCPMC10026551
OpenAlexW4322493012

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read69
table measurements read3
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.