Evidence map›Paper›PMID 36945625›Full record

ArticleResearch square2023

Defining the Infant Male Urobiome and Moving Towards Mechanisms in Urobiome Research.

Maria Hadjifrangiskou, Seth Reasoner, Viktor Flores, Gerald Van Horn, Grace Morales, Leslie Peard, Benjamin Abelson, Carmila Manuel, Jessica Lee, Bailey Baker and 3 more

Open access · greenFull text readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Maria HadjifrangiskouVanderbilt University Medical Center.ORCID 0000-0003-4249-8997
Seth ReasonerVanderbilt University Medical Center.ORCID 0000-0002-7791-1641
Viktor FloresVanderbilt University Medical Center.ORCID 0000-0002-4200-4611
Gerald Van HornVanderbilt University Medical Center.
Grace MoralesVanderbilt University Medical Center.
Leslie PeardVanderbilt University Medical Center.ORCID 0000-0002-5222-4079
Benjamin AbelsonVanderbilt University Medical Center.
Carmila ManuelVanderbilt University Medical Center.
Jessica LeeVanderbilt University Medical Center.
Bailey BakerVanderbilt University Medical Center.
Timothy WilliamsVanderbilt University Medical Center.
Jonathan SchmitzVanderbilt University Medical Center.
Douglass ClaytonVanderbilt University Medical Center.
Vanderbilt University Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Chemical Biology of Infectious Diseases (CBID) Training ProgramT32AI112541 · NIAID · VANDERBILT UNIVERSITY · PI Eric P Skaar · 2015 to 2026
$4.0M
The Vanderbilt Urologic Infection Repository, a Resource for Personalized Clinical DiscoveryP20DK123967 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAYTON, DOUGLASS BROOKS, HADJIFRANGISKOU, MARIA · 2019 to 2020
$680k
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Copper Sensing in Uropathogenic Escherichia coliF30AI169748 · NIAID · VANDERBILT UNIVERSITY · PI Seth A Reasoner · 2023 to 2026
$156k
Defining a Molecular Signature of Uropathogenic Escherichia coliF31DK131902 · NIDDK · VANDERBILT UNIVERSITY · PI MORALES, GRACE · 2022 to 2023
$65k
NIAID NIH HHS F30 AI169748NIAID NIH HHS T32 AI112541NIDDK NIH HHS F31 DK131902NIDDK NIH HHS P20 DK123967NIGMS NIH HHS T32 GM007347NIH HHS S10 OD026929
6 · The paper itself

Abstract

The urinary bladder harbors a community of microbes termed the urobiome, which remains understudied. In this study, we present the urobiome of healthy infant males from samples collected by transurethral catheterization. Using a combination of extended culture and amplicon sequencing, we identify several common bacterial genera that can be further investigated for their effects on urinary health across the lifespan. Many genera were shared between all samples suggesting a consistent urobiome composition among this cohort. We note that, for this cohort, early life exposures including mode of birth (vaginal vs. Caesarean section), or prior antibiotic exposure did not influence urobiome composition. In addition, we report the isolation of culturable bacteria from the bladders of these infant males, including

Indexed as

pangenomepediatric urologyurinary microbiomeurinary tract infectionUrobiome

Identifiers

PMID36945625
PMCPMC10029076
OpenAlexW4323355897

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read24
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.