ArticlebioRxiv : the preprint server for biology2023
Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone.
Vivianne E Morrison, Matthew G Houpert, Jonathan B Trapani, Asa A Brockman, Philip J Kingsley, Ketaki A Katdare, Hillary M Layden, Gabriela Nguena-Jones, Alexandra J Trevisan, Kathleen A Maguire-Zeiss and 4 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors at 5 institutions in 1 country.
Vivianne E MorrisonVanderbilt University Department of Biochemistry.
Matthew G HoupertVanderbilt University Department of Biochemistry.
Jonathan B TrapaniVanderbilt University Department of Biochemistry.
Asa A BrockmanVanderbilt University Department of Cell and Developmental Biology.
Philip J KingsleyVanderbilt University Department of Biochemistry.
Ketaki A KatdareVanderbilt Brain Institute.
Hillary M LaydenVanderbilt University Department of Biochemistry.
Gabriela Nguena-JonesVanderbilt University Department of Biochemistry.
Alexandra J TrevisanVanderbilt University Department of Biochemistry.
Kathleen A Maguire-ZeissGeorgetown University Department of Neuroscience.
Lawrence J MarnettVanderbilt University Department of Biochemistry.
Gregory J BixTulane University Center for Clinical Neuroscience Research.
Rebecca A IhrieVanderbilt University Department of Cell and Developmental Biology.
Bruce D CarterVanderbilt University Department of Biochemistry.
Allen Institute for Brain Science · USVanderbilt University · USTulane University · USGeorgetown University · USSt. Jude Children's Research Hospital · US
Funding
MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9MIdentifying mTOR Dependent Periods During Brain DevelopmentR01NS118580 · NINDS · VANDERBILT UNIVERSITY · PI ESS, KEVIN C, IHRIE, REBECCA A · 2020 to 2024
$2.1MPAR-1 Signaling and HANDR01NS083410 · NINDS · GEORGETOWN UNIVERSITY · PI CONANT, KATHERINE E, MAGUIRE-ZEISS, KATHLEEN ANNE · 2013 to 2017
$1.9MThe role of the glial engulfment receptor Jedi1 in regulating sensory neuron functionR01NS102365 · NINDS · VANDERBILT UNIVERSITY · PI CARTER, BRUCE D · 2018 to 2022
$1.7MLoss of Jedi-1 impairs microglia phagocytosis, resulting in reduced postnatal neurogenesis in the ventricular-subventricular zone.F32HD107930 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI MORRISON, VIVIANNE E · 2022 to 2022
$77kNICHD NIH HHS F32 HD107930NIDDK NIH HHS T32 DK007563NINDS NIH HHS R01 NS083410NINDS NIH HHS R01 NS102365NINDS NIH HHS R01 NS118580
6 · The paper itselfAbstract
Microglia are the primary phagocytes in the central nervous system and are responsible for clearing dead cells generated during development or disease. The phagocytic process shapes the phenotype of the microglia, which affects the local environment. A unique population of microglia reside in the ventricular-subventricular zone (V-SVZ) of neonatal mice, but how they influence this neurogenic niche is not well-understood. Here, we demonstrate that phagocytosis creates a pro-neurogenic microglial phenotype in the V-SVZ and that these microglia phagocytose apoptotic cells via the engulfment receptor Jedi-1. Deletion of
Indexed as
aging/neurodegenerationMicroglianeuroinflammationphagocytosissequencingTREM2
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PMID36945622
PMCPMC10028845
OpenAlexW4323355267
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