Evidence map›Paper›PMID 36945607›Full record

ArticlebioRxiv : the preprint server for biology2023

Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of

Linus Manubens-Gil, Meritxell Pons-Espinal, Thomas Gener, Inmaculada Ballesteros-Yañez, María Martínez de Lagrán, Mara Dierssen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Linus Manubens-GilSEU-Allen Joint Center, Institute for Brain and Intelligence, Southeast University (SEU), China.
Meritxell Pons-EspinalDepartment of Pathology and Experimental Therapeutics, Bellvitge University Hospital-IDIBELL, Barcelona, Spain.
Thomas GenerCatalan Institute of Nanoscience and Nanotechnology (ICN2), Campus UAB, Bellaterra, Barcelona, Spain.
Inmaculada Ballesteros-YañezDepartment of Inorganic and Organic Chemistry and Biochemistry, Faculty of Medicine, University of Castilla-La Mancha, Ciudad Real, Spain (UCLM), CRIB, Spain.
María Martínez de LagránCentre for Genomic Regulation (CRG), BIST, Spain.
Mara DierssenCentre for Genomic Regulation (CRG), BIST, Spain.
Centre for Biomedical Network Research on Rare Diseases · ESBellvitge University Hospital · ESInstitut Català de Nanociència i Nanotecnologia · ESSoutheast University · CNUniversity of Castilla-La Mancha · ES

Funding

New methods and theories to interrogate organizational principles from single cell to neuronal networksR01EB028159 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIERSSEN, MARA, YE, BING · 2019 to 2019
$951k
NIBIB NIH HHS R01 EB028159
6 · The paper itself

Abstract

Abnormal dendritic arbors, dendritic spine "dysgenesis" and excitation inhibition imbalance are main traits assumed to underlie impaired cognition and behavioral adaptation in intellectual disability. However, how these modifications actually contribute to functional properties of neuronal networks, such as signal integration or storage capacity is unknown. Here, we used a mouse model overexpressing

Identifiers

PMID36945607
PMCPMC10028951
OpenAlexW4323848609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.