Evidence map›Paper›PMID 36945533›Full record

ArticlebioRxiv : the preprint server for biology2023

Pharmacological characterization of the endocannabinoid sensor GRAB

Simar Singh, Dennis Sarroza, Anthony English, Maya McGrory, Ao Dong, Larry Zweifel, Benjamin B Land, Yulong Li, Michael R Bruchas, Nephi Stella

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Simar SinghDepartment of Pharmacology, University of Washington, Seattle, USA.
Dennis SarrozaDepartment of Pharmacology, University of Washington, Seattle, USA.
Anthony EnglishDepartment of Pharmacology, University of Washington, Seattle, USA.
Maya McGroryDepartment of Pharmacology, University of Washington, Seattle, USA.
Ao DongPeking University School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Larry ZweifelDepartment of Pharmacology, University of Washington, Seattle, USA.
Benjamin B LandDepartment of Pharmacology, University of Washington, Seattle, USA.
Yulong LiPeking University School of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Michael R BruchasDepartment of Pharmacology, University of Washington, Seattle, USA.
Nephi StellaDepartment of Pharmacology, University of Washington, Seattle, USA.
University of Washington · USPeking University · CN

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
Novel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3M
DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER37DA033396 · NIDA · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2018 to 2026
$3.8M
Cannabidiol and terpenoid interactions in amygdalar regulation of pain statesR01AT011524 · NCCIH · UNIVERSITY OF WASHINGTON · PI Benjamin Land · 2022 to 2026
$2.1M
DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER01DA033396 · NIDA · WASHINGTON UNIVERSITY · PI BRUCHAS, MICHAEL R. · 2013 to 2017
$1.9M
Molecular mechanism of ABHD6 enzymatic activity in neuronsR21NS118130 · NINDS · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2020 to 2020
$428k
ABHD6 and amphetamine stimulated locomotionR21DA047626 · NIDA · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI, ZWEIFEL, LARRY S · 2019 to 2020
$409k
Dissecting PFC Endocannabinoid-THC -regulated circuits in movement behaviorF31DA055448 · NIDA · UNIVERSITY OF WASHINGTON · PI ENGLISH, ANTHONY EDWARD · 2022 to 2024
$131k
NCCIH NIH HHS R01 AT011524NIDA NIH HHS F31 DA055448NIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA033396NIDA NIH HHS R21 DA047626NIDA NIH HHS R37 DA033396NIGMS NIH HHS T32 GM007750NINDS NIH HHS R21 NS118130NINDS NIH HHS U01 NS113358
6 · The paper itself

Abstract

Introduction: The endocannabinoids ( Methods: GRAB Results: 2-AG increased GRAB Conclusions: 2-AG and SR1 modulate the GRAB

Identifiers

PMID36945533
PMCPMC10028790
OpenAlexW4323667650

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.