Evidence map›Paper›PMID 36945508›Full record

ArticlebioRxiv : the preprint server for biology2023

Genome mining unveils a class of ribosomal peptides with two amino termini.

Hengqian Ren, Shravan R Dommaraju, Chunshuai Huang, Haiyang Cui, Yuwei Pan, Marko Nesic, Lingyang Zhu, David Sarlah, Douglas A Mitchell, Huimin Zhao

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hengqian RenDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0001-7045-6036
Shravan R DommarajuDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-0565-1748
Chunshuai HuangCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-3126-2340
Haiyang CuiCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0001-8360-0447
Yuwei PanDepartment of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Marko NesicDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0001-6856-5313
Lingyang ZhuSchool of Chemical Sciences, NMR Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-6657-271X
David SarlahDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-8736-8953
Douglas A MitchellDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-9564-0953
Huimin ZhaoDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-9069-6739
University of Illinois Urbana-Champaign · US

Funding

A Scalable Platform to Discover Antimicrobials of Ribosomal OriginR01AI144967 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Douglas Alan Mitchell, WILFRED A. VAN DER DONK · 2019 to 2026
$6.0M
Genomics-Accelerated Natural Product DiscoveryR01GM123998 · NIGMS · VANDERBILT UNIVERSITY · PI MITCHELL, DOUGLAS ALAN · 2017 to 2024
$2.6M
NIAID NIH HHS R01 AI144967NIGMS NIH HHS R01 GM123998
6 · The paper itself

Abstract

The era of inexpensive genome sequencing and improved bioinformatics tools has reenergized the study of natural products, including the ribosomally synthesized and post-translationally modified peptides (RiPPs). In recent years, RiPP discovery has challenged preconceptions about the scope of post-translational modification chemistry, but genome mining of new RiPP classes remains an unsolved challenge. Here, we report a RiPP class defined by an unusual (

Identifiers

PMID36945508
PMCPMC10028931
OpenAlexW4323539480

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.