Evidence map›Paper›PMID 36945497›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.

Barbara Hollunder, Jill L Ostrem, Ilkem Aysu Sahin, Nanditha Rajamani, Simón Oxenford, Konstantin Butenko, Clemens Neudorfer, Pablo Reinhardt, Patricia Zvarova, Mircea Polosan and 29 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 15 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors at 17 institutions in 8 countries.

Barbara HollunderDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Jill L OstremMovement Disorders and Neuromodulation Centre, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Ilkem Aysu SahinDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Nanditha RajamaniDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Simón OxenfordDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Konstantin ButenkoCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Clemens NeudorferCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pablo ReinhardtDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Patricia ZvarovaDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Mircea PolosanUniv. Grenoble Alpes, Grenoble, France.
Harith AkramDepartment of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK.
Matteo VissaniDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Chencheng ZhangDepartment of Neurosurgery, Rujin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Bomin SunDepartment of Neurosurgery, Rujin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pavel NavratilDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Martin M ReichDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Jens VolkmannDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Fang-Cheng YehDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Juan Carlos BaldermannDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Till A DembekDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Veerle Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Eduardo Joaquim Lopes AlhoClinic of Pain and Functional Neurosurgery, São Paulo, Brazil.
Paulo Roberto FranceschiniDepartment of Neurology and Neurosurgery, University of Caxias do Sul, Rio Grande do Sul, Brazil.
Pranav NandaDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Carsten FinkeDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Andrea A KühnDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Darin D DoughertyDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
R Mark RichardsonDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hagai BergmanThe Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel.
Mahlon R DeLongDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Alberto MazzoniThe BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.
Luigi M RomitoParkinson and Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Himanshu TyagiDepartment of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK.
Ludvic ZrinzoDepartment of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK.
Eileen M JoyceDepartment of Clinical and Movement Neurosciences, University College London Queen Square Institute of Neurology, London, UK.
Stephan ChabardesUniv. Grenoble Alpes, Grenoble, France.
Philip A StarrDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Ningfei LiDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Andreas HornDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEHarvard University · USNational Hospital for Neurology and Neurosurgery · GBBrigham and Women's Hospital · USHumboldt-Universität zu Berlin · DEUniversitätsklinikum Würzburg · DEUniversity of Cologne · DEEinstein Center for Neurosciences Berlin · DEInserm · FRShanghai Jiao Tong University · CNUniversity of California, San Francisco · USEmory University · USFondazione IRCCS Istituto Neurologico Carlo Besta · ITHebrew University of Jerusalem · ILScuola Superiore Sant'Anna · ITUniversidade de Caxias do Sul · BRUniversity of Pittsburgh · US

Funding

Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9M
Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4M
NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NINDS NIH HHS R01 NS127892
6 · The paper itself

Abstract

Frontal circuits play a critical role in motor, cognitive, and affective processing - and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)function remains largely elusive. Here, we study 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregate the frontal cortex into circuits that became dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to rostral, ranging from interconnections with sensorimotor cortices in dystonia, with the primary motor cortex in Tourette's syndrome, the supplementary motor area in Parkinson's disease, to ventromedial prefrontal and anterior cingulate cortices in obsessive-compulsive disorder. Our findings highlight the integration of deep brain stimulation with brain connectomics as a powerful tool to explore couplings between brain structure and functional impairment in the human brain.

Indexed as

ConnectomeDeep Brain Stimulation (DBS)DystoniaObsessive-Compulsive Disorder (OCD)Parkinson’s disease (PD)Structural ConnectivitySubthalamic Nucleus (STN)Tourette’s syndrome (TS)

Identifiers

PMID36945497
PMCPMC10029043
OpenAlexW4323655368

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.