Evidence map›Paper›PMID 36945490›Full record

ArticleResearch square2023

Transcriptional Induction of NF-kB-Inducing Kinase by E2F4/5 Facilitates Collective Invasion of Glioma Cells.

Kathryn Pflug, Dong Lee, Kassandra McFadden, Linda Herrera, Raquel Sitcheran

Open access · greenFull text readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kathryn PflugTexas A&M Health Science Center.
Dong LeeTexas A&M Health Science Center.
Kassandra McFaddenTexas A&M Health Science Center.
Linda HerreraTexas A&M Health Science Center.
Raquel SitcheranTexas A&M Health Science Center.
Texas A&M Health Science Center · US

Funding

Pathway-Specific NF-kappaB Regulatory Networks in GliomaR01NS082554 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SITCHERAN, RAQUEL · 2014 to 2022
$2.5M
NINDS NIH HHS R01 NS082554
6 · The paper itself

Abstract

The prognosis of high-grade gliomas, such as glioblastoma multiforme (GBM), is extremely poor due to the highly invasive nature of these aggressive cancers. Previous work has demonstrated that TNF-weak like factor (TWEAK) induction of the noncanonical NF-κB pathway increases the invasiveness of glioma cells in an NF-κB-inducing kinase (NIK)-dependent manner. While NIK activity is predominantly regulated at the posttranslational level, we show here that NIK (

Identifiers

PMID36945490
PMCPMC10029079
OpenAlexW4323355280

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read30
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.