Evidence map›Paper›PMID 36945434›Full record

ArticlebioRxiv : the preprint server for biology2023

Functional profiling of the

Christopher J Giuliano, Kenneth J Wei, Faye M Harling, Benjamin S Waldman, Madeline A Farringer, Elizabeth A Boydston, Tammy C T Lan, Raina W Thomas, Alice L Herneisen, Allen G Sanderlin and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Christopher J GiulianoWhitehead Institute, Cambridge, MA.
Kenneth J WeiWhitehead Institute, Cambridge, MA.
Faye M HarlingWhitehead Institute, Cambridge, MA.
Benjamin S WaldmanWhitehead Institute, Cambridge, MA.
Madeline A FarringerDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Elizabeth A BoydstonWhitehead Institute, Cambridge, MA.
Tammy C T LanWhitehead Institute, Cambridge, MA.
Raina W ThomasWhitehead Institute, Cambridge, MA.
Alice L HerneisenWhitehead Institute, Cambridge, MA.
Allen G SanderlinBiology Department, MIT, Cambridge, MA.
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Jeffrey D DvorinDivision of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Sebastian LouridoWhitehead Institute, Cambridge, MA.
IIT@MIT · USBoston Children's Hospital · USWhitehead Institute for Biomedical Research · USJohns Hopkins University · US

Funding

Development and maintenance of chronic toxoplasmosisR01AI158501 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2021 to 2025
$3.3M
Control of parasite invasion by a microneme protein complex conserved in ApicomplexansR01AI144369 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2020 to 2024
$2.4M
NIAID NIH HHS R01 AI144369NIAID NIH HHS R01 AI158501
6 · The paper itself

Abstract

Within a host, pathogens encounter a diverse and changing landscape of cell types, nutrients, and immune responses. Examining host-pathogen interactions in animal models can therefore reveal aspects of infection absent from cell culture. We use CRISPR-based screens to functionally profile the entire genome of the model apicomplexan parasite

Identifiers

PMID36945434
PMCPMC10028831
OpenAlexW4323670031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.