Evidence map›Paper›PMID 36945409›Full record

ArticlebioRxiv : the preprint server for biology2023

Temporal Coordination of the Transcription Factor Response to H

Elizabeth Jose, Woody March-Steinman, Bryce A Wilson, Lisa Shanks, Andrew L Paek

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Elizabeth JoseMolecular and Cellular Biology, University of Arizona, Tucson, AZ, 85721.
Woody March-SteinmanApplied Mathematics, University of Arizona, Tucson, AZ, 85721.
Bryce A WilsonMolecular and Cellular Biology, University of Arizona, Tucson, AZ, 85721.
Lisa ShanksMolecular and Cellular Biology, University of Arizona, Tucson, AZ, 85721.
Andrew L PaekMolecular and Cellular Biology, University of Arizona, Tucson, AZ, 85721.

Funding

Computational and Mathematical Modeling of Biomedical SystemsT32GM132008 · NIGMS · UNIVERSITY OF ARIZONA · PI Ryan Gutenkunst, JOANNA MASEL · 2019 to 2026
$2.3M
Dynamics of the FOXO transcription factor networkR01GM130864 · NIGMS · UNIVERSITY OF ARIZONA · PI PAEK, ANDREW LUTHER · 2019 to 2023
$1.7M
NIGMS NIH HHS R01 GM130864NIGMS NIH HHS T32 GM132008
6 · The paper itself

Abstract

The p53 and FOXO transcription factors (TFs) share many similarities despite their distinct evolutionary origins. Both TFs are activated by a variety of cellular stresses and upregulate genes in similar pathways including cell-cycle arrest and apoptosis. Oxidative stress from excess H

Identifiers

PMID36945409
PMCPMC10028935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.