Evidence map›Paper›PMID 36945400›Full record

ArticlebioRxiv : the preprint server for biology2023

Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics.

Merve S Zeden, Laura A Gallagher, Emilio Bueno, Aaron C Nolan, Jongsam Ahn, Dhananjay Shinde, Fareha Razvi, Margaret Sladek, Órla Burke, Eoghan O'Neill and 4 more

Open access · greenFull text readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Merve S ZedenMicrobiology, School of Biological and Chemical Sciences, University of Galway, Ireland.
Laura A GallagherMicrobiology, School of Biological and Chemical Sciences, University of Galway, Ireland.
Emilio BuenoDepartment of Molecular Biology, Umeå University, MIMS - Laboratory for Molecular Infection Medicine Sweden, Umeå, Sweden.
Aaron C NolanMicrobiology, School of Biological and Chemical Sciences, University of Galway, Ireland.
Jongsam AhnDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Dhananjay ShindeDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Fareha RazviDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Margaret SladekDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Órla BurkeMicrobiology, School of Biological and Chemical Sciences, University of Galway, Ireland.
Eoghan O'NeillDepartment of Clinical Microbiology, Royal College of Surgeons in Ireland.
Paul D FeyDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Felipe CavaDepartment of Molecular Biology, Umeå University, MIMS - Laboratory for Molecular Infection Medicine Sweden, Umeå, Sweden.
Vinai C ThomasDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
James P O'GaraMicrobiology, School of Biological and Chemical Sciences, University of Galway, Ireland.
University of Nebraska Medical Center · USOllscoil na Gaillimhe – University of Galway · IEUmeå University · SERoyal College of Surgeons in Ireland · IE

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
The role of arginine catabolic pathways in modulating staphylococcal fitnessR01AI125588 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THOMAS, VINAI · 2018 to 2022
$1.9M
NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125588
6 · The paper itself

Abstract

Central metabolic pathways controls virulence and antibiotic resistance, and constitute potential targets for antibacterial drugs. In Author summary: High-level resistance to penicillin-type (β-lactam) antibiotics significantly limits the therapeutic options for patients with MRSA infections necessitating the use of newer agents, for which reduced susceptibility has already been described. Here we report for the first time that the central metabolism pentose phosphate pathway controls MRSA resistance to penicillin-type antibiotics. We comprehensively demonstrated that mutation of the PPP gene

Identifiers

PMID36945400
PMCPMC10028837
OpenAlexW4323538490

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read139
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.