Evidence map›Paper›PMID 36945371›Full record

ArticlebioRxiv : the preprint server for biology2023

Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types.

Vikram Agarwal, Fumitaka Inoue, Max Schubach, Beth K Martin, Pyaree Mohan Dash, Zicong Zhang, Ajuni Sohota, William Stafford Noble, Galip Gürkan Yardimci, Martin Kircher and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 51 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Vikram AgarwalDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Fumitaka InoueDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.
Max SchubachBerlin Institute of Health of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany.
Beth K MartinDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Pyaree Mohan DashBerlin Institute of Health of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany.
Zicong ZhangInstitute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.
Ajuni SohotaDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.
William Stafford NobleDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Galip Gürkan YardimciDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Martin KircherBerlin Institute of Health of Health at Charité - Universitätsmedizin Berlin, 10178, Berlin, Germany.
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Nadav AhituvDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158, USA.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin · DEUniversity of California, San Francisco · USUniversity of Washington · USHoward Hughes Medical Institute · USInstitut Pasteur · FRKyoto University · JPOregon Health & Science University · US

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
RESEARCH TRAINING IN HEMATOLOGYT32HL007093 · NHLBI · UNIVERSITY OF WASHINGTON · PI Janis L Abkowitz · 1985 to 2026
$13.9M
EDAC: ENCODE Data Analysis CenterU24HG009446 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GERSTEIN, MARK BENDER, WENG, ZHIPING · 2017 to 2022
$10.4M
Massively parallel characterization of variants and elements impacting transcriptional regulation in dynamic cellular systemsUM1HG011966 · NHGRI · UNIVERSITY OF WASHINGTON · PI Nadav Ahituv, Jay Ashok Shendure · 2021 to 2026
$9.7M
Massively parallel reporter assays and genome editing of ENCODE predicted regulatory elementsUM1HG009408 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SHENDURE, JAY ASHOK · 2017 to 2021
$7.6M
Functional characterization of obesity-associated OXTR enhancersR01DK124769 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, VAISSE, CHRISTIAN · 2020 to 2024
$3.7M
NHGRI NIH HHS U24 HG009446NHGRI NIH HHS UM1 HG009408NHGRI NIH HHS UM1 HG011966NHLBI NIH HHS T32 HL007093NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK124769
6 · The paper itself

Abstract

The human genome contains millions of candidate

Identifiers

PMID36945371
PMCPMC10028905
OpenAlexW4323663453

What OpenQuestion holds

Textfull text, public
LicenceCC BY-ND
measurements read46
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.