Evidence map›Paper›PMID 36945257›Full record

ArticleCognitive therapy and research2023

Stress-Related Exhaustion, Polygenic Cognitive Potential, and Cognitive Test Performance - A General Population Study.

Laila Ketvel, Liisa Keltikangas-Järvinen, Katja Pahkala, Markus Juonala, Ari Ahola-Olli, Terho Lehtimäki, Jorma Viikari, Olli Raitakari, Suvi Rovio, Aino Saarinen

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In one paragraph

Article in Cognitive therapy and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Laila KetvelDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014 Helsinki, Finland.
Liisa Keltikangas-JärvinenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014 Helsinki, Finland.
Katja PahkalaResearch Centre for Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Markus JuonalaDepartment of Medicine, Division of Medicine, University of Turku, Turku University Hospital, Turku, Finland.
Ari Ahola-OlliPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Finnish Cardiovascular Research Center, Fimlab Laboratories, Tampere, Finland.
Jorma ViikariDepartment of Medicine, Division of Medicine, University of Turku, Turku University Hospital, Turku, Finland.
Olli RaitakariResearch Centre for Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Suvi RovioResearch Centre for Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Aino SaarinenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014 Helsinki, Finland.ORCID 0000-0003-4495-8360
University of Turku · FIUniversity of Helsinki · FIBoston University · USTampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We investigated whether stress-related exhaustion (chronic or short-term, and co-occurring with depression or not) is related to cognitive performance and whether polygenic cognitive potential modifies these associations. Methods: The participants were from the Young Finns Study (N = 541-1273). Stress-related exhaustion was assessed using the Maastricht Questionnaire, depressive symptoms with the Beck Depression Inventory, and cognitive performance with subtests of the Cambridge Neuropsychological Test Automated Battery, measuring visuospatial learning, reaction time, sustained attention, and executive function. Cognitive performance and depression were assessed in 2011, and exhaustion in 2001, 2007, and 2011. A polygenic score for cognitive potential was calculated based on a GWAS on intelligence. Results: High stress-related exhaustion, especially chronic, was associated with slower reaction time. Only clinical levels of depression were related to slower reaction time. Polygenic cognitive potential did not modify these associations. There were no differences in cognitive performance between individuals with co-occurring exhaustion and depression vs. those with only either condition. Conclusion: Stress-related exhaustion, especially if chronic, seems to relate to slower reactions. Co-occurring exhaustion and depression may not have additive effects on cognitive performance. High polygenic cognitive potential may not protect from or predispose to harmful effects of exhaustion or depression on reaction time. Supplementary Information: The online version contains supplementary material available at 10.1007/s10608-023-10354-z.

Indexed as

BurnoutDepressionGeneticLongitudinalPolygenicVital exhaustion

Identifiers

PMID36945257
PMCPMC10023621
OpenAlexW4319233947

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read34
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.