ArticleJournal of burn care & research : official publication of the American Burn Association2023
A Histological and Clinical Study of MatriDerm® Use in Burn Reconstruction.
Article in Journal of burn care & research : official publication of the American Burn Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Photothermal interaction of a 1927 nm Thulium laser with MatriDerm: an in vitro study.Lasers in medical science · 2026Article
- Cellularized Skin Substitute Bioengineering for Regenerative Medicine: Cell Sources, Culture Strategies, and Transition Toward Defined, Xeno-Free Culture Systems.Advanced healthcare materials · 2026Review
- Defining dermal matrices: Results of a global Delphi panel in surgical reconstruction.JPRAS open · 2026Article
- Pilot Study: DermiSphere: A Novel Hydrogel with Collagen Microspheres Dermal Regeneration Template.Plastic and reconstructive surgery. Global open · 2026Article
- Three-dimensional Bovine Collagen-Elastin Matrix in Soft Tissue Reconstruction: No Detectable Bovine DNA After 1 Year.Plastic and reconstructive surgery. Global open · 2026Article
- Pediatric Burns: Biological and Tissue Engineered Skin Substitutes-A Systematic Review.Journal of clinical medicine · 2025Review
- The Potential of Functional Hydrogels in Burns Treatment.Gels (Basel, Switzerland) · 2025Review
- Design and Applications of Extracellular Matrix Scaffolds in Tissue Engineering and Regeneration.Cells · 2025Review
- The Role of Skin Substitutes in the Therapeutical Management of Burns Affecting Functional Areas.Medicina (Kaunas, Lithuania) · 2025Review
- The Reconstruction of Various Complex Full-Thickness Skin Defects with a Biodegradable Temporising Matrix: A Case Series.European burn journal · 2025Article
- A Collagen-Elastin Regenerative Dermal Matrix May Generate Unfavorable Results in Head and Neck Postburn Scar Reconstruction: A Case Series.Medicina (Kaunas, Lithuania) · 2025Article
- Reconstruction of hand surgical wounds after pseudo-syndactyly correction or squamous cell carcinoma resection in patients affected from epidermolysis bullosa: a monocentric experience with a collagen-elastin dermal matrix substitute.Dermatology reports · 2025Article
- Recurrence of Acne inversa of the penis - two-stage reconstruction with MatriDermGMS Interdisciplinary plastic and reconstructive surgery DGPW · 2025Article
- Update burn surgery: overview of current multidisciplinary treatment concepts.Innovative surgical sciences · 2024Review
- Review
- Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation.Advanced healthcare materials · 2024Review
- Microporous Polylactic Acid Scaffolds Enable Fluorescence-Based Perfusion Imaging of Intrinsic In Vivo Vascularization.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dermal substitutes are well established in the reconstructive ladder. MatriDerm® (Dr. Otto Suwelack Skin & Health Care AG, Billerbeck, Germany) is a single-layer dermal substitute composed of a bovine collagen (type I, III, and V) and elastin hydrolysate, that allows for immediate split-thickness skin grafting (SSG). The aim of this study was to histologically characterize the integration of MatriDerm® when used during burns surgery reconstruction. Eight subjects with nine burn scars and one acute burn wound underwent reconstruction with MatriDerm® and an immediate SSG. MatriDerm® integration and skin graft take were assessed with serial biopsies performed at weeks 1, 2, 3, and 4 and months 2, 3, 6, 9, and 12. Biopsies were assessed with standard special stains and immunohistochemistry, and representative slides were imaged with a transmission electron microscope. Patient satisfaction and clinical scar outcome were assessed with the Vancouver Scar Scale and a patient questionnaire. Histological analysis showed similar stages of wound healing as shown in other dermal templates but on a different timescale. There is early evidence of vascularization and an inflammatory infiltrate in the first 2 weeks. MatriDerm® is resorbed earlier than other dermal substitutes, with evidence of resorption at week 3, to be completely replaced by a neodermis at 2 months. The use of MatriDerm® in reconstruction with immediate skin grafting is supported histologically with early evidence of vascularization to support an epidermal autograft. Future histological studies may help further characterize the ideal dermal substitute.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.