Evidence map›Paper›PMID 36945012›Full record

ArticleSystematic reviews2023

Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol.

MengQi Zhang, Dean A Fergusson, Rahul Sharma, Ciel Khoo, Asher A Mendelson, Braedon McDonald, Kimberly F Macala, Neha Sharma, Sean E Gill, Kirsten M Fiest and 8 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

MengQi ZhangFaculty of Medicine, University of Ottawa, 451 Smyth Rd #2044, Ottawa, ON, K1H 8M5, Canada.ORCID 0000-0001-9822-1319
Dean A FergussonFaculty of Medicine, University of Ottawa, 451 Smyth Rd #2044, Ottawa, ON, K1H 8M5, Canada. dafergusson@ohri.ca.ORCID 0000-0002-3389-2485
Rahul SharmaFaculty of Medicine, University of Ottawa, 451 Smyth Rd #2044, Ottawa, ON, K1H 8M5, Canada.ORCID 0000-0001-7413-4253
Ciel KhooClinical Epidemiology Program, Blueprint Translational Group, Ottawa Hospital Research Institute, 501 Smyth Box 511, Ottawa, ON, K1H 8L6, Canada.ORCID 0000-0002-9762-3241
Asher A MendelsonDepartment of Internal Medicine, Section of Critical Care Medicine, Rady Faculty of Health Sciences, University of Manitoba, 820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada.ORCID 0000-0003-2108-4752
Braedon McDonaldDepartment of Critical Care Medicine, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.ORCID 0000-0001-8936-8992
Kimberly F MacalaDepartment of Critical Care Medicine, Royal Alexandra Hospital, University of Alberta, 2-214 Clinical Science Building, 8440-112Th Street, Edmonton, AB, T6G 2B7, Canada.ORCID 0000-0002-9127-217X
Neha SharmaDepartment of Medical Sciences and Thrombosis and Atherosclerosis Research Institute, McMaster University, 237 Barton St East, Hamilton, ON, L8L 2X2, Canada.ORCID 0000-0002-9481-7673
Sean E GillCentre for Critical Illness Research, Lawson Health Research Institutes, Victoria Research Labs, A6-134, 800 Commissioners Road Ease, London, ON, N6A 5W9, Canada.ORCID 0000-0003-4791-1576
Kirsten M FiestDepartment of Critical Care Medicine, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.ORCID 0000-0002-7299-6594
Christian LehmannDepartment of Anesthesia, Pain Management and Perioperative Medicine, II Health Sciences Centre, 5850 College Street, Halifax, NS, B3H 1X5, Canada.ORCID 0000-0001-6419-9168
Risa ShorrLearning Services, The Ottawa Hospital, Ottawa, ON, Canada.
Forough JahandidehClinical Epidemiology Program, Blueprint Translational Group, Ottawa Hospital Research Institute, 501 Smyth Box 511, Ottawa, ON, K1H 8L6, Canada.ORCID 0000-0001-9731-0854
Stephane L BourqueDepartment of Anesthesiology & Pain Medicine, Katz Group Centre for Pharmacy and Health Research, University of Alberta, 3-020H, Edmonton, AB, T6G 2E1, Canada.ORCID 0000-0001-6375-7404
Patricia C LiawDepartment of Medicine and Thrombosis and Atherosclerosis Research Institute, McMaster University and Hamilton Health Sciences, 237 Barton St East, Hamilton, ON, L8L 2X2, Canada.ORCID 0000-0002-7783-1393
Alison Fox-RobichaudDepartment of Medicine and Thrombosis and Atherosclerosis Research Institute, McMaster University and Hamilton Health Sciences, 237 Barton St East, Hamilton, ON, L8L 2X2, Canada.ORCID 0000-0001-9912-3606
Manoj M LaluClinical Epidemiology Program, Blueprint Translational Group, Ottawa Hospital Research Institute, 501 Smyth Box 511, Ottawa, ON, K1H 8L6, Canada. mlalu@toh.ca.ORCID 0000-0002-0322-382X
Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform
Ottawa Hospital · CAThrombosis and Atherosclerosis Research Institute · CAUniversity of Alberta · CAUniversity of Ottawa · CAUniversity of Calgary · CAQueen Elizabeth II Health Sciences Centre · CAUniversity of Manitoba · CAWestern University · CA

Funding

CIHR 438017
6 · The paper itself

Abstract

backgroundThe importance of investigating sex- and gender-dependent differences has been recently emphasized by major funding agencies. Notably, the influence of biological sex on clinical outcomes in sepsis is unclear, and observational studies suffer from the effect of confounding factors. The controlled experimental environment afforded by preclinical studies allows for clarification and mechanistic evaluation of sex-dependent differences. We propose a systematic review to assess the impact of biological sex on baseline responses to disease induction as well as treatment responses in animal models of sepsis. Given the lack of guidance surrounding sex-based analyses in preclinical systematic reviews, careful consideration of various factors is needed to understand how best to conduct analyses and communicate findings.

methodsMEDLINE and Embase will be searched (2011-present) to identify preclinical studies of sepsis in which any intervention was administered and sex-stratified data reported. The primary outcome will be mortality. Secondary outcomes will include organ dysfunction, bacterial load, and IL-6 levels. Study selection will be conducted independently and in duplicate by two reviewers. Data extraction will be conducted by one reviewer and audited by a second independent reviewer. Data extracted from included studies will be pooled, and meta-analysis will be conducted using random effects modeling. Primary analyses will be stratified by animal age and will assess the impact of sex at the following time points: pre-intervention, in response to treatment, and post-intervention. Risk of bias will be assessed using the SYRCLE's risk-of-bias tool. Illustrative examples of potential methods to analyze sex-based differences are provided in this protocol. DISCUSSION: Our systematic review will summarize the current state of knowledge on sex-dependent differences in sepsis. This will identify current knowledge gaps that future studies can address. Finally, this review will provide a framework for sex-based analysis in future preclinical systematic reviews. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42022367726.

Indexed as

SepsisAnimalsDisease Models, AnimalMeta-Analysis as TopicSystematic Reviews as TopicAnimal modelsInterventionSepsisSexSystematic review

Identifiers

PMID36945012
PMCPMC10029211
OpenAlexW4328050864

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read23
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.