Evidence map›Paper›PMID 36944850›Full record

ArticleScientific reports2023

Role of triggering receptor expressed on myeloid cells-1 in the mechanotransduction signaling pathways that link low shear stress with inflammation.

Martin Liu, Anastasios Nikolaos Panagopoulos, Usama M Oguz, Saurabhi Samant, Charu Hasini Vasa, Devendra K Agrawal, Yiannis S Chatzizisis

Open access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Martin Liu *Computational Cardiovascular Simulations Center, Division of Cardiovascular Medicine, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 1124, Miami, FL, 33136, USA.
Anastasios Nikolaos Panagopoulos *Cardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Usama M Oguz *Computational Cardiovascular Simulations Center, Division of Cardiovascular Medicine, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 1124, Miami, FL, 33136, USA.
Saurabhi SamantCardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Charu Hasini VasaComputational Cardiovascular Simulations Center, Division of Cardiovascular Medicine, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 1124, Miami, FL, 33136, USA.
Devendra K AgrawalDepartment of Translational Research, Western University of Health Science, Pomona, CA, USA.
Yiannis S ChatzizisisComputational Cardiovascular Simulations Center, Division of Cardiovascular Medicine, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 1124, Miami, FL, 33136, USA. ychatzizisis@icloud.com.
University of Miami · USUniversity of Nebraska Medical Center · USWestern University of Health Sciences · US

Funding

Patient-Specific Simulations to Guide Coronary Bifurcation StentingR01HL144690 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CHATZIZISIS, IOANNIS S · 2019 to 2023
$3.9M
NHLBI NIH HHS R01 HL144690
6 · The paper itself

Abstract

This study sought to investigate the role of triggering receptor expressed on myeloid cells-1 (TREM-1) in the mechanotransduction signaling pathways that link low shear stress with inflammation. Human coronary artery endothelial cells, human coronary artery smooth muscle cells, and THP-1 monocytes were co-cultured and exposed to varying endothelial shear stress (ESS) conditions: low (5 ± 3 dynes/cm

Indexed as

AtherosclerosisMechanotransduction, CellularSignal TransductionTriggering Receptor Expressed on Myeloid Cells-1Endothelial CellsHumansInflammationInflammation MediatorsInflammation MediatorsTREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1

Identifiers

PMID36944850
PMCPMC10030555
OpenAlexW4353017625

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read38
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.