Evidence map›Paper›PMID 36944760›Full record

ArticleJournal of neurology2023

Good vibrations: tactile cueing for freezing of gait in Parkinson's disease.

E C Klaver, J P P van Vugt, B R Bloem, R J A van Wezel, J Nonnekes, M C Tjepkema-Cloostermans

Abstract read
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E C KlaverDepartment of Neurology and Clinical Neurophysiology, Medical Spectrum Twente, Enschede, The Netherlands. emilie.klaver@donders.ru.nl.ORCID http://orcid.org/0000-0003-1082-5527
J P P van VugtDepartment of Neurology and Clinical Neurophysiology, Medical Spectrum Twente, Enschede, The Netherlands.
B R BloemDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Centre of Expertise for Parkinson and Movement Disorders, Radboud University Medical Centre, Nijmegen, The Netherlands.
R J A van WezelDepartment of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Heyendaalseweg 135, P.O. Box 9102, 6525 AJ, Nijmegen, The Netherlands.
J NonnekesDepartment of Rehabilitation, Donders Institute for Brain, Cognition and Behaviour, Centre of Expertise for Parkinson and Movement Disorders, Radboud University Medical Centre, Nijmegen, The Netherlands.
M C Tjepkema-CloostermansDepartment of Neurology and Clinical Neurophysiology, Medical Spectrum Twente, Enschede, The Netherlands.

Funding

Michael J. Fox Foundation for Parkinson's Research ID 16457Nederlandse Organisatie voor Wetenschappelijk Onderzoek 17619
6 · The paper itself

Abstract

backgroundCueing strategies can alleviate freezing of gait (FOG) in people with Parkinson's disease (PD). We evaluated tactile cueing delivered via vibrating socks, which has the benefit of not being noticeable to bystanders.

objectiveTo evaluate the effect of tactile cueing compared to auditory cueing on FOG.

methodsThirty-one persons with PD with FOG performed gait tasks during both ON and OFF state. The effect of open loop and closed loop tactile cueing, as delivered by vibrating socks, was compared to an active control group (auditory cueing) and to a baseline condition (uncued gait). These four conditions were balanced between subjects. Gait tasks were videotaped and annotated for FOG by two experienced raters. Motion data were collected to analyze spatiotemporal gait parameters. Responders were defined as manifesting a relative reduction of > 10% in the percent time frozen compared to uncued gait.

resultsThe average percent time frozen during uncued gait was 11.2% in ON and 21.5% in OFF state. None of the three tested cueing modalities affected the percentage of time frozen in either the ON (p = 0.20) or OFF state (p = 0.12). The number of FOG episodes and spatiotemporal gait parameters were also not affected. We found that 22 out of 31 subjects responded to cueing, the response to the three types of cueing was highly individual.

conclusionsCueing did not improve FOG at the group level; however, tactile as well as auditory cueing improved FOG in many individuals. This highlights the need for a personalized approach when using cueing to treat FOG.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseCuesGaitHumansVibrationCuesFeedbackGait disorders/neurologicHaptic feedback technologyParkinson’s diseaseParkinson’s disease/therapy*Wearable electronic devices*

Identifiers

PMID36944760
PMCPMC10267272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.