Evidence map›Paper›PMID 36944451›Full record

SynthesisBMJ open respiratory research2023

Lung cancer resection in patients with underlying usual interstitial pneumonia: a meta-analysis.

Akshay Jatin Patel, Gareth I Walters, Steven Watkins, Vanessa Rogers, Hazem Fallouh, Maninder Kalkat, Babu Naidu, Ehab S Bishay

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. [Surgical Management of Lung Cancer in Patients with Interstitial Lung Disease].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026
    Review
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  6. TheJournal of clinical medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Akshay Jatin PatelInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK ajp.788@gmail.com.
Gareth I WaltersInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Steven WatkinsDepartment of Radiation Oncology, University Hospitals Birmingham, Birmingham, UK.
Vanessa RogersInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Hazem FallouhInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Maninder KalkatInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Babu NaiduInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Ehab S BishayInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
University of Birmingham · GBNIHR Surgical Reconstruction and Microbiology Research Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePatients with lung cancer with underlying idiopathic pulmonary fibrosis and usual interstitial pneumonia (UIP) pattern on CT represent a very high-risk group in terms of postoperative UIP acute exacerbations (AEs) and in-hospital mortality. We sought to investigate the outcomes in these patients.

methodsWe carried out a meta-analysis, searching four international databases from 1 January 1947 to 27 April 2022, for studies in any language reporting on the acute postoperative outcomes of patients with lung cancer undergoing surgical resection with underlying UIP (the primary outcome). Random effects meta-analyses (DerSimonian and Laird) were conducted. We analysed the difference in incidence of postoperative AE as well as the difference in long-term overall survival among subpopulations. These were stratified by the extent of surgical resection, with meta-regression testing (uniivariate and multivariate) according to the stage of disease, operative decision making and country of origin. This study was registered with PROSPERO (CRD42022319245).

resultsThe overall incidence of AE of UIP postoperatively from 10 studies (2202 patients) was 14.6% (random effects model, 95% CI 9.8 to 20.1, I

conclusionsWith appropriate implementation of perioperative measures such as screening for high-risk cases, appropriate use of steroids, antifibrotics and employing sublobar resection in select cases, the risk of local recurrence versus in-hospital mortality from AEUIP can be balanced and long-term survival can be achieved in a super-selected group of patients. Further investigation in the form of a randomised study is warranted.

Indexed as

Idiopathic Pulmonary FibrosisLung Diseases, InterstitialLung NeoplasmsHumansLungRetrospective StudiesInterstitial FibrosisLung CancerThoracic Surgery

Identifiers

PMID36944451
PMCPMC10032402
OpenAlexW4328137526

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.