Evidence map›Paper›PMID 36944385›Full record

ArticleOphthalmology. Glaucoma

Forecasting Risk of Future Rapid Glaucoma Worsening Using Early Visual Field, OCT, and Clinical Data.

Patrick Herbert, Kaihua Hou, Chris Bradley, Greg Hager, Michael V Boland, Pradeep Ramulu, Mathias Unberath, Jithin Yohannan

Open access · greenAbstract read
In one paragraph

Article in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  6. Review
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  8. A multi-label transformer-based deep learning approach to predict focal visual field progression.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  9. Article
  10. Article
  11. Big data in visual field testing for glaucoma.Taiwan journal of ophthalmology
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Patrick HerbertMalone Center For Engineering in Healthcare, Johns Hopkins University, Baltimore, Maryland.
Kaihua HouMalone Center For Engineering in Healthcare, Johns Hopkins University, Baltimore, Maryland.
Chris BradleyWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Greg HagerMalone Center For Engineering in Healthcare, Johns Hopkins University, Baltimore, Maryland.
Michael V BolandMassachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
Pradeep RamuluWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Mathias UnberathMalone Center For Engineering in Healthcare, Johns Hopkins University, Baltimore, Maryland.
Jithin YohannanMalone Center For Engineering in Healthcare, Johns Hopkins University, Baltimore, Maryland; Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland. Electronic address: jyohann1@jhmi.edu.
Johns Hopkins University · USMassachusetts Eye and Ear Infirmary · US

Funding

A Comprehensive Strategy to Detect Glaucoma Worsening Earlier and With Fewer TestsK23EY032204 · NEI · JOHNS HOPKINS UNIVERSITY · PI YOHANNAN, JITHIN · 2021 to 2025
$956k
NEI NIH HHS K23 EY032204
6 · The paper itself

Abstract

purposeTo assess whether we can forecast future rapid visual field (VF) worsening using deep learning models (DLMs) trained on early VF, OCT, and clinical data.

designA retrospective cohort study. SUBJECTS: In total, 4536 eyes from 2962 patients. Overall, 263 (5.80%) eyes underwent rapid VF worsening (mean deviation slope less than -1 dB/year across all VFs).

methodsWe included eyes that met the following criteria: (1) followed for glaucoma or suspect status; (2) had at least 5 longitudinal reliable VFs (VF

main outcome measuresThe AUC of DLMs when forecasting rapidly worsening eyes.

resultsModel V

conclusionsDeep learning models can forecast future rapid glaucoma worsening with modest to high performance when trained using data from early in the disease course. Including baseline data from multiple modalities and subsequent visits improves performance beyond using VF data alone. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

GlaucomaVolatile Organic CompoundsHumansRetrospective StudiesTomography, Optical CoherenceVisual FieldsVisual Field TestsVolatile Organic CompoundsDeep learningforecastingglaucomatransformers

Identifiers

PMID36944385
PMCPMC10509314
OpenAlexW4327923849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.