ArticleCirculation. Cardiovascular imaging2023
Apical Ischemia Is a Universal Feature of Apical Hypertrophic Cardiomyopathy.
Article in Circulation. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Multimodality Imaging in Apical Hypertrophic Cardiomyopathy: Can Echocardiography Learn from Cardiac Magnetic Resonance?Diagnostics (Basel, Switzerland) · 2025Review
- Echocardiographic assessment of apical morphology and dynamics in hypertension and apical hypertrophic cardiomyopathy.Scientific reports · 2025Article
- Article
- Electrocardiographic precedence with rapid anatomical progression in apical hypertrophic cardiomyopathy: a case report.BMC cardiovascular disorders · 2025Article
- Apical Hypertrophic Cardiomyopathy With Endomyocardial Calcification: A Multimodality Imaging-Based Case Report.Cureus · 2025Article
- A Practical Approach to Multimodality Imaging in Hypertrophic Cardiomyopathy.Journal of clinical medicine · 2025Review
- Critical evaluation of ECG parameter analysis in hypertrophic cardiomyopathy staging: A closer look.Journal of arrhythmia · 2025Article
- ST-Segment Elevation Myocardial Infarction Presentation in Apical Hypertrophic Cardiomyopathy.JACC. Case reports · 2025Article
- Exploring the Current Status of Risk Stratification in Hypertrophic Cardiomyopathy: From Risk Models to Promising Techniques.Journal of cardiovascular development and disease · 2025Review
- The Mechanical and Perfusion Basis of Exercise Limitation in Apical Hypertrophic Cardiomyopathy.JACC. Advances · 2025Article
- Clinical Course and Treatment of Patients With Apical Aneurysms Due to Hypertrophic Cardiomyopathy.JACC. Advances · 2024Article
- Apical hypertrophic cardiomyopathy: pathophysiology, diagnosis and management.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- Assessment of left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy and coronary artery disease.The international journal of cardiovascular imaging · 2024Article
- Advances in Multi-Modality Imaging in Hypertrophic Cardiomyopathy.Journal of clinical medicine · 2024Review
- Imaging Advances in Heart Failure.Cardiac failure review · 2024Review
- Diagnostic confidence with quantitative cardiovascular magnetic resonance perfusion mapping increases with increased coverage of the left ventricle.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Echocardiographic diagnosis of hypertrophic cardiomyopathy confined to the left ventricular apex in a cat.JFMS open reportsArticle
- Society for Cardiovascular Magnetic Resonance 2024 Cases of SCMR case series.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceReview
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundApical hypertrophic cardiomyopathy (ApHCM) accounts for ≈10% of hypertrophic cardiomyopathy cases and is characterized by apical hypertrophy, apical cavity obliteration, and tall ECG R waves with ischemic-looking deep T-wave inversion. These may be present even with <15 mm apical hypertrophy (relative ApHCM). Microvascular dysfunction is well described in hypertrophic cardiomyopathy. We hypothesized that apical perfusion defects would be common in ApHCM.
methodsA 2-center study using cardiovascular magnetic resonance short- and long-axis quantitative adenosine vasodilator stress perfusion mapping. One hundred patients with ApHCM (68 overt hypertrophy [≥15 mm] and 32 relative ApHCM) were compared with 50 patients with asymmetrical septal hypertrophy hypertrophic cardiomyopathy and 40 healthy volunteer controls. Perfusion was assessed visually and quantitatively as myocardial blood flow and myocardial perfusion reserve.
resultsApical perfusion defects were present in all overt ApHCM patients (100%), all relative ApHCM patients (100%), 36% of asymmetrical septal hypertrophy hypertrophic cardiomyopathy, and 0% of healthy volunteers (
conclusionsApical perfusion defects are universally present in ApHCM at all stages. Its ubiquitous presence along with characteristic ECG suggests ischemia may play a disease-defining role in ApHCM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.