Evidence map›Paper›PMID 36943876›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex in

Muhammad T Naseem, Robin Beaven, Takashi Koyama, Sehrish Naz, Sheng-Yuan Su, David P Leader, Dan A Klaerke, Kirstine Calloe, Barry Denholm, Kenneth V Halberg

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Entropy generation in the Malpighian tubule and its comparison with the mammalian nephron.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The cryptonephridial/rectal complex: an evolutionary adaptation for water and ion conservation.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  7. Molecular biology of the cell · 2024
    Article
  8. NaInternational journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad T NaseemDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, Copenhagen DK-2100, Denmark.ORCID 0000-0002-6225-9777
Robin BeavenDeanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH8 9AG, UK.ORCID 0000-0001-5941-1187
Takashi KoyamaDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, Copenhagen DK-2100, Denmark.ORCID 0000-0003-4203-114X
Sehrish NazDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, Copenhagen DK-2100, Denmark.
Sheng-Yuan SuDeanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH8 9AG, UK.
David P LeaderInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-0635-1843
Dan A KlaerkeDepartment of Veterinary and Animal Sciences, Section for Pathobiological Sciences, University of Copenhagen DK-1870, Frederiksberg, Denmark.
Kirstine CalloeDepartment of Veterinary and Animal Sciences, Section for Pathobiological Sciences, University of Copenhagen DK-1870, Frederiksberg, Denmark.ORCID 0000-0002-1777-7938
Barry DenholmDeanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH8 9AG, UK.ORCID 0000-0001-5785-2552
Kenneth V HalbergDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, Copenhagen DK-2100, Denmark.ORCID 0000-0002-5903-7196

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More than half of all extant metazoan species on earth are insects. The evolutionary success of insects is linked with their ability to osmoregulate, suggesting that they have evolved unique physiological mechanisms to maintain water balance. In beetles (Coleoptera)-the largest group of insects-a specialized rectal ("cryptonephridial") complex has evolved that recovers water from the rectum destined for excretion and recycles it back to the body. However, the molecular mechanisms underpinning the remarkable water-conserving functions of this system are unknown. Here, we introduce a transcriptomic resource, BeetleAtlas.org, for the exceptionally desiccation-tolerant red flour beetle

Indexed as

TriboliumAnimalsAntiportersProtonsRectumWaterAntiportersProtonsWatercation/H+ antiportergeneticsrectal complexsecondary cellTribolium castaneum

Identifiers

PMID36943876
PMCPMC10068851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.