Evidence map›Paper›PMID 36943642›Full record

ArticleJournal of applied genetics2023

The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing.

Zhongzheng Bian, Ziqian Wu, Nan Liu, Xiao Jiang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhongzheng BianDepartment of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
Ziqian WuDepartment of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
Nan LiuDepartment of Emergency Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.
Xiao JiangDepartment of Emergency Intensive Care Unit, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China. jx_kaishi@163.com.ORCID http://orcid.org/0000-0003-1821-4827
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 RNA vaccines are smartly designed to increase the synonymous codon usage by introducing multiple U-to-C mutations. This design would elevate the translation efficiency of vaccine RNAs. However, we found evidence to reason that the designed cytidines might be converted to uridines again by C-to-U RNA deamination in host cells. This C-to-U mechanism might be a main factor that affects the efficacy and safety of RNA vaccines.

Indexed as

COVID-19COVID-19 VaccinesBNT162 VaccineHumansmRNA VaccinesRNA EditingRNA, ViralSARS-CoV-2BNT162 VaccineCOVID-19 VaccinesmRNA VaccinesRNA, ViralC-to-U RNA editingEfficacySARS-CoV-2Synonymous codon usageVaccines

Identifiers

PMID36943642
PMCPMC10028319
OpenAlexW4328049102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.