Evidence map›Paper›PMID 36943590›Full record

SynthesisDigestive diseases and sciences2023

Over-the-Scope Clips Versus Standard Endoscopic Treatment for First Line Therapy of Non-variceal Upper Gastrointestinal Bleeding: Systematic Review and Meta-Analysis.

Alec E Faggen, Faisal Kamal, Wade Lee-Smith, Muhammad Ali Khan, Sachit Sharma, Ashu Acharya, Zohaib Ahmed, Umer Farooq, Alexis Bayudan, Richard McLean and 4 more

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Alec E FaggenDivision of Gastroenterology, University of California- San Francisco, San Francisco, CA, USA.
Faisal KamalDivision of Gastroenterology, Thomas Jefferson University Hospital, 132 South 10th Street, Main Building, Suite 480, Philadelphia, PA, 19107, USA. fkamal36@gmail.com.ORCID http://orcid.org/0000-0002-6842-506X
Wade Lee-SmithMulford Health Sciences Library, University of Toledo, Toledo, OH, USA.
Muhammad Ali KhanDepartment of Gastroenterology, Hepatology and Nutrition, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sachit SharmaDepartment of Medicine, University of Toledo, Toledo, OH, USA.
Ashu AcharyaDepartment of Medicine, University of Toledo, Toledo, OH, USA.
Zohaib AhmedDepartment of Medicine, University of Toledo, Toledo, OH, USA.
Umer FarooqDepartment of Medicine, Loyola Medicine/MacNeal Hospital, Berwyn, IL, USA.
Alexis BayudanDivision of Gastroenterology, University of California- San Francisco, San Francisco, CA, USA.
Richard McLeanDivision of Gastroenterology, University of California- San Francisco, San Francisco, CA, USA.
Patrick AvilaDivision of Gastroenterology, University of California- San Francisco, San Francisco, CA, USA.
Sun-Chuan DaiDivision of Gastroenterology, University of California- San Francisco, San Francisco, CA, USA.
Craig A MunroeDivision of Gastroenterology, University of California- San Francisco, San Francisco, CA, USA.
Abdul KouandaDivision of Gastroenterology, University of California- San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of Toledo · USMacNeal Hospital · USThe University of Texas MD Anderson Cancer Center · USThomas Jefferson University Hospital · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsOver-The-Scope Clips (OTSC) use have shown promising results for first line treatment of non-variceal upper gastrointestinal bleeding (NVUGIB). We conducted this meta-analysis to compare outcomes in patients treated with OTSC versus standard endoscopic intervention for first line endoscopic treatment of NVUGIB.

methodsWe reviewed several databases from inception to December 9, 2022 to identify studies comparing OTSC and standard treatments as the first line treatment for NVUGIB. The outcomes assessed included re-bleeding, initial hemostasis, need for vascular embolization, mortality, need for repeat endoscopy, 30 day readmission rate, and need for surgery. Pooled risk ratios (RR) with 95% confidence intervals (CI) were calculated using random effect model. Heterogeneity was assessed by I

resultsWe included 11 studies with 1608 patients (494 patients in OTSC group and 1114 patients in control group). OTSC use was associated with significantly lower risk of re-bleeding (RR, 0.58; 95% CI 0.41-0.82). We found no significant difference in rates of initial hemostasis (RR, 1.05; 95% CI 0.99- 1.11), vascular embolization rates (RR, 0.93; 95% CI 0.40- 2.13), need for repeat endoscopy (RR, 0.78; 95% CI 0.40-1.49), 30 day readmission rate (RR, 0.59; 95% CI 0.17-2.01), need for surgery (RR, 0.81; 95% CI 0.29-2.28) and morality (RR, 0.69; 95% CI 0.38-1.23).

conclusionsOTSC are associated with significantly lower risk of re-bleeding compared to standard endoscopic treatments when used as first line endoscopic therapy for NVUGIB.

Indexed as

Embolization, TherapeuticHemostasis, EndoscopicEndoscopy, GastrointestinalGastrointestinal HemorrhageHumansRecurrenceMeta-analysisOver the scope clipsPrimary treatmentUpper GI bleeding

Identifiers

PMID36943590
OpenAlexW4328048718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.