Evidence map›Paper›PMID 36943516›Full record

ArticleJournal of neurology2023

COVID19-associated new-onset movement disorders: a follow-up study.

Susanne A Schneider, Soaham Desai, Onanong Phokaewvarangkul, Elena Cecilia Rosca, Jirada Sringean, Pria Anand, Gary Álvarez Bravo, Francisco Cardoso, Anna M Cervantes-Arslanian, Harshad Chovatiya and 20 more

Open access · hybridFull text read
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 13 countries.

Susanne A SchneiderDepartment of Neurology, Ludwig Maximilians University Munich, Marchioninistr. 15, 81377, Munich, Germany. susanne.schneider@med.uni-muenchen.de.ORCID http://orcid.org/0000-0001-7283-1995
Soaham DesaiDepartment of Neurology, Shree Krishna Hospital, Pramukhswami Medical College, Bhaikaka University, Karamsad, Anand, Gujarat, India.
Onanong PhokaewvarangkulChulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, 1873 Rama 4 Road, Bangkok, Thailand.
Elena Cecilia RoscaDepartment of Neurology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Jirada SringeanChulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, 1873 Rama 4 Road, Bangkok, Thailand.
Pria AnandDepartments of Neurology, Neurosurgery, and Medicine Boston University School of Medicine and Boston Medical Center, Boston, USA.
Gary Álvarez BravoNeuroimmunology and Multiple Sclerosis Unit of Girona, University Hospital Dr. Josep Trueta of Girona, Girona, Catalonia, Spain.
Francisco CardosoMovement Disorders Unit, Neurology Service, Internal Medicine Department, UFMG, Belo Horizonte, Brazil.
Anna M Cervantes-ArslanianDepartments of Neurology, Neurosurgery, and Medicine Boston University School of Medicine and Boston Medical Center, Boston, USA.
Harshad ChovatiyaDepartment of Neurology, Shree Krishna Hospital, Pramukhswami Medical College, Bhaikaka University, Karamsad, Anand, Gujarat, India.
David CrosiersFaculty of Medicine and Health Sciences, Translational Neurosciences, University of Antwerp, Antwerp, Belgium.
Femke DijkstraFaculty of Medicine and Health Sciences, Translational Neurosciences, University of Antwerp, Antwerp, Belgium.
Conor FearonDivision of Neurology, Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital - UHN, University of Toronto, Toronto, ON, Canada.
Francisco GrandasMovement Disorders Unit, Neurology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Eric GuedjInstitut Fresnel, Nuclear Medicine Department, Aix Marseille Univ, APHM, CNRS, Centrale Marseille, Timone Hospital, CERIMED, Marseille, France.
Antonio Méndez-GuerreroNeurology Department, Hospital 12 de Octubre, Madrid, Spain.
Muhammad HassanShaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.
Joseph JankovicParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Anthony E LangDivision of Neurology, Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital - UHN, University of Toronto, Toronto, ON, Canada.
Karim MakhoulParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Lorenzo MuccioliDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Sarah A O'SheaDepartment of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, USA.
Vahid Reza OstovanClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Javier Ricardo Perez-SanchezMovement Disorders Unit, Neurology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Ritesh RamdhaniZucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Victoria Ros-CastellóNeurology Department, Ramon y Cajal University Hospital, Madrid, Spain.
Christina SchulteDepartmemt of Neurology and Neurorehabilitation, Hospital Zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Duesseldorf, Kempen, Germany.
Priyank ShahPrivya Neurology Clinic, Ahmedabad, Gujarat, India.
Lars WojteckiDepartmemt of Neurology and Neurorehabilitation, Hospital Zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Duesseldorf, Kempen, Germany.
Pramod Kumar PalDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.
Baylor College of Medicine · USBoston University · USChulalongkorn University · THHospital General Universitario Gregorio Marañón · ESHospital zum Heiligen Geist · DEShree Krishna Hospital · INUniversity of Antwerp · BEUniversity of Toronto · CACentre National de la Recherche Scientifique · FRClínica Girona · ESColumbia University · USHofstra University · USInstituto Cajal · ESLudwig-Maximilians-Universität München · DENational Institute of Mental Health and Neurosciences · INResearch Institute Hospital 12 de Octubre · ESShaheed Zulfiqar Ali Bhutto Institute of Science and Technology · PKShiraz University of Medical Sciences · IRUniversidade Federal de Minas Gerais · BRUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurological symptoms are common manifestation in acute COVID-19. This includes hyper- and hypokinetic movement disorders. Data on their outcome, however, is limited.

methodsCases with new-onset COVID-19-associated movement disorders were identified by searching the literature. Authors were contacted for outcome data which were reviewed and analyzed.

resultsMovement disorders began 12.6 days on average after the initial onset of COVID-19. 92% of patients required hospital admission (mean duration 23 days). In a fraction of patients (6 of 27; 22%; 4 males/2 females, mean age 66.8 years) the movement disorder (ataxia, myoclonus, tremor, parkinsonism) was still present after a follow-up period of 7.5 ± 3 weeks. Severe COVID-19 in general and development of encephalopathy were risk factors, albeit not strong predictors, for the persistence.

conclusionsThe prognosis of new-onset COVID-19-associated movement disorder appears to be generally good. The majority recovered without residual symptoms within several weeks or months. Permanent cases may be due to unmasking of a previous subclinical movement disorder or due to vascular/demyelinating damage. Given the relatively low response rate of one third only and the heterogeneity of mechanisms firm conclusions on the (long-term) outome cannot, however, be drawn.

Indexed as

COVID-19Movement DisordersAgedFemaleFollow-Up StudiesHumansMaleRisk FactorsTremorCOVIDLong covidMovement disorderMyoclonus ataxiaOutcomeParkinsonismSars-CoV2

Identifiers

PMID36943516
PMCPMC10029788
OpenAlexW4328048721

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read25
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.