Evidence map›Paper›PMID 36943469›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

NSAID-associated acute kidney injury in hospitalized children - a prospective Pediatric Nephrology Research Consortium study.

Jason M Misurac, Matthew M Grinsell, JoAnn Hansen Narus, Sherene Mason, Mahmoud Kallash, Sharon P Andreoli

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Jason M MisuracDivision of Pediatric Nephrology, Dialysis, and Transplantation, University of Iowa Stead Family Children's Hospital, 200 Hawkins Dr, Iowa City, IA, 52242, USA. Jason-Misurac@uiowa.edu.ORCID http://orcid.org/0000-0002-6800-7650
Matthew M GrinsellDivision of Pediatric Nephrology, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.
JoAnn Hansen NarusDivision of Pediatric Nephrology, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.
Sherene MasonDivision of Pediatric Nephrology, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Farmington, CT, USA.
Mahmoud KallashDivision of Pediatric Nephrology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.
Sharon P AndreoliDepartment of Pediatrics, Pediatric Nephrology, Indiana University Medical Center, Indianapolis, IN, USA.
Primary Children's Hospital · USNationwide Children's Hospital · USUniversity Medical Center · USUniversity of Connecticut · USUniversity of Iowa Stead Family Children’s Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) in children has serious short-term and long-term consequences. We sought 1) to prospectively describe NSAID-associated AKI in hospitalized children; 2) to determine if NSAID-associated AKI was more severe in younger children < 5 years; and 3) to follow outcomes after hospitalization for NSAID-associated AKI.

methodsThis was a prospective, multi-center study in hospitalized children 1 month to 18 years. Parents/guardians were given a brief questionnaire to determine the dosing, duration, and type of NSAIDs given. Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine criteria were used to stage AKI severity. Patients with other causes of AKI were excluded (e.g., other nephrotoxins, sepsis, malignancy, etc.).

resultsWe identified 25 patients with NSAID-associated AKI, accounting for 3.1% of AKI. All 25 had AKI upon hospital presentation. The median age was 15.5 years, and 20/25 (80%) had volume depletion. Median duration of NSAID use was 2 days, and 63% of patients took the normal recommended NSAID dose. Median hospital length of stay was 4 days, and none required dialysis. At the most recent estimated glomerular filtration rate (eGFR) after discharge (available in 17/25 patients), only 4/17 (24%) had eGFR ≥ 90 ml/min/1.73 m

conclusionsNSAID-associated AKI usually occurs with recommended NSAID dosing in the setting of dehydration. Follow-up after AKI showed a substantial rate of CKD. Therefore, we recommend that NSAIDs should not be used in dehydrated children. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Acute Kidney InjuryNephrologyAdolescentAnti-Inflammatory Agents, Non-SteroidalChildChild, HospitalizedHumansProspective StudiesRenal DialysisRetrospective StudiesRisk FactorsAnti-Inflammatory Agents, Non-SteroidalAcute kidney injuryChronic kidney diseaseDehydrationNon-steroidal anti-inflammatory drugsPediatric nephrology research consortiumPediatrics

Identifiers

PMID36943469
OpenAlexW4328048125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.